Bioavailability of Ubiquinol in Huntington Disease

Status Completed

Clinical Trial Summary

The death of brain cells in Huntington Disease (HD) is thought to be associated with a lack of normal cell energy and harmful brain substances called free radicals. Coenzyme Q10 (CoQ) is a marketed nutritional supplement that may prove useful in HD because it increases cell energy and combats free radicals.

Most studies of CoQ have looked at only one formulation of CoQ ("ubiquinone") in HD. The purpose of the study is to find out if people that switch from the common formulation of CoQ ("ubiquinone") to a different formulation ("ubiquinol") have higher levels of CoQ in their blood after taking the same dose. The investigators also want to find out if this different formulation is tolerable for individuals with HD.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Bio-availability Study, Intervention Model: Single Group Assignment, Masking: Open Label

Related Conditions & MeSH terms

Huntington Disease

Clinical Trial Details

NCT number	NCT00980694
Study type	Interventional
Source	University of Rochester
Contact
Status	Completed
Phase	Phase 1
Start date	September 2009
Completion date	July 2012

View Details

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