Huntington Disease Clinical Trial
Official title:
A Phase III Multicenter, Double-Blind, Parallel-Group, Placebo Controlled Study to Measure the Effect of Riluzole 50 mg b.i.d. Over a Period of Three Years on the Progression of Huntington's Disease
Primary objective:
- The primary objective of the study is to establish that riluzole slows down (1) the
decrease in total functional capacity (TFC), (2) the increase of the motor score of the
Unified Huntington's Disease Rating Scale (UHDRS) as well as (3) the increase of a
combined score of these.
Secondary objectives:
Secondary objectives are to assess
- changes in the other UHDRS subscales
- the number of patients who need antichoreic treatment and the time until this treatment
has to be initiated
- the safety/tolerability of riluzole in Huntington patients
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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