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Impact Hesperetin in Combination With Sucrose on Blood Glucose Regulation

Hunger Clinical Trial

Official title:
Einfluss Des süßmodulierenden Polyphenols Hesperetin in Kombination Mit Saccharose Auf Die Blutglukose-Regulierung Und Energieaufnahme in Abhängigkeit Der Süßwahrnehmung Teil 2

Clinical Trial Summary

The aim of this cross-over intervention study is to investigate the influence of hesperetin applied in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution and an isocaloric sucrose-only solution on markers of energy metabolism

Clinical Trial Description

The study is designed as a randomised cross-over intervention study with three arms. The aim is to investigate the influence of a 10% sucrose solution, corresponding to the sugar content of a conventional soft drink, compared to an equally sweet-tasting 7% sucrose solution in combination with 50 mg/L of the polyphenol hesperetin, and a less sweet 7% sucrose solution w/o hesperetin on time-dependent blood glucose fluctuations and ad libitum energy intake in metabolically healthy male volunteers. To investigate the underlying mechanisms, the individual appetite score, metabolic and hormonal responses to the interventions and will be measured. In addition, the participants' individual thresholds for sweet taste, preference and consumption for sweet-tasting foods such as sugar and sweeteners, and their body composition will be recorded as potential influencing factors. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06340087
Study type Interventional
Source University of Vienna
Contact Barbara Lieder, PhD
Phone 4314277
Email Barbara.Lieder@univie.ac.at
Status Recruiting
Phase Early Phase 1
Start date March 31, 2024
Completion date March 31, 2025
View Details
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