Hunger Clinical Trial
Official title:
Einfluss Des süßmodulierenden Polyphenols Hesperetin in Kombination Mit Saccharose Auf Die Blutglukose-Regulierung Und Energieaufnahme in Abhängigkeit Der Süßwahrnehmung
Verified date | November 2023 |
Source | University of Vienna |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of this cross-over intervention study is to investigate the influence of the sweet-modulating substance hesperetin in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution on markers of energy metabolism.
Status | Completed |
Enrollment | 33 |
Est. completion date | November 15, 2023 |
Est. primary completion date | June 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - male - healthy - non-smoking - normal taste responses towards sweet taste Exclusion Criteria: - female - regular smokers - disturbed glucose and/or lipid metabolism - regular intake of medication - known allergies against one of the test compounds - ageusia - alcohol or drug addiction - intake of antibiotics within the past 2 months |
Country | Name | City | State |
---|---|---|---|
Austria | Christian Doppler Laboratory for Taste Research | Vienna |
Lead Sponsor | Collaborator |
---|---|
University of Vienna |
Austria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in blood glucose concentration | Change compared to baseline in blood glucose concentration [mg/dL] in plasma samples after drinking the test solution | 15, 30, 60, 90, and 120 minutes after drinking the test solution | |
Primary | Change in appetite score | Change compared to baseline in the subjective rating of the individual feeling of hunger, fullness, as well as appetite for a snack or for something sweet on a digital visual analog scale in comparison to baseline | Difference between before and 120 minutes after drinking of the test solution | |
Primary | Change in food intake | Ad libitum food intake from a standardized breakfast | 120 minutes after drinking of the test solution | |
Secondary | Change in blood glucose regulating hormones | Change compared to baseline in Insulin, Glucagon-like peptide 1, and Gastric inhibitory polypeptide concentrations [mmol/L] in plasma samples after drinking the test solution | 15, 30, 60, 90, and 120 minutes after drinking the test solution | |
Secondary | Change in satiety hormones | Change compared to baseline in Polypeptide Y, grehlin, cholecystokinin, and serotonin concentrations [mmol/L] in plasma samples after drinking the test | 15, 30, 60, 90, and 120 minutes after drinking the test solution | |
Secondary | Change in circulating miRNA | Change compared to baseline in circulating extracellular vesicles and their miRNA composition | 15, 30, 60, 90, and 120 minutes after drinking the test solution |
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