Hunger Clinical Trial
Official title:
Eating Disinhibition and Vagal Tone Moderate the Postprandial Response to Glycaemic Load: A Randomised Controlled Trial
Verified date | July 2016 |
Source | Swansea University |
Contact | n/a |
Is FDA regulated | No |
Health authority | United Kingdom: Research Ethics Committee |
Study type | Interventional |
Reducing the glycaemic load (GL) of the diet may benefit appetite control but its utility is complicated by psychological influences on eating. Disinhibited behaviour, a risk factor for overconsumption, is characterized by reduced prefrontal cortex activity, which in turn directly modulates vagal tone; a phenomenon inversely associated with blood glucose (BG) and insulin levels. This double blind randomised controlled trial explores the influence of disinhibited eating and vagal tone (heart rate variability) on the postprandial response to GL and hunger.
Status | Completed |
Enrollment | 66 |
Est. completion date | December 2015 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 30 Years |
Eligibility |
Inclusion Criteria: - Young healthy adults who scored either high or low on the Three factor eating questionnaire disinhibition subscale Exclusion Criteria: Participants were excluded if they - had a cardiovascular or metabolic disorder - gastrointestinal problems - were pregnant - had a current diagnosis of a mood or eating disorder - and/or were taking medications or herbal supplements to manage body weight or control appetite |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United Kingdom | Swansea University | Swansea | West Glamorgan |
Lead Sponsor | Collaborator |
---|---|
Swansea University |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in blood glucose | Blood glucose was monitored from finger pricks using an ExacTech sensor (Medisense Britain Limited) that using an enzymic method, coupled with microelectronic measurement. Change in blood glucose from baseline to after 30 minutes will assess the speed of incline. | From baseline to 30 minutes | Yes |
Primary | Change in blood glucose | As above to assess the speed of decline. | from 30 to 150minutes | Yes |
Secondary | Hunger | Participants were asked to respond to the question "how hungry are you feeling right now" on a single 100mm visual analogue scale anchored by "Not at all" and "Extremely". | 30, 150 minutes | No |
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