Hunger Clinical Trial
— SEPAOfficial title:
Effects of Hydrolysed Porcine Proteins on Muscle Protein Synthesis and Appetite
The purpose of the study is to obtain a better understanding of how hydrolysed porcine
proteins affect the human metabolism, including the effects on muscle protein synthesis,
appetite and secretion of gastrointestinal hormones.
It is hypothesised that hydrolysed porcine proteins will stimulate muscle protein synthesis,
affect appetite and the secretion of gastrointestinal hormones similar to hydrolysed whey
protein.
Status | Completed |
Enrollment | 21 |
Est. completion date | July 2016 |
Est. primary completion date | July 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 20 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Healthy young men - Normal weight (BMI 18.5-25 kg/m2) - 22-40 years Exclusion Criteria: - Vegetarians - Weight change >3kg within 2 months prior to start of the study - Regular participation in cardio/strength training within 6 months prior to (and during) the study (>1 per wk) - Use of alcohol >14 drinks/wk - Drug abuse - Smoking - Regular consumption of protein supplements - Use of over-the-counter or prescription medication that influences body weight, appetite or metabolism - Diabetes Mellitus - Dyslipidemia - Diseases, which influence metabolism - Donation of blood 3 months prior to start of (and during) the study - Subjects with a hemoglobin value < 8 mol/L (measured at screening) - Participation in other clinical studies 1 month prior to start of (and during) the study - Subjects who are unable to give an informed consent. |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Denmark | Department of Nutrition, Exercise and Sports | Frederiksberg |
Lead Sponsor | Collaborator |
---|---|
University of Copenhagen | Arla Food Ingredients Group P/S, DC Ingredients, Svineafgiftsfonden |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Urate in urine and blood | Explorative parameter | Blood samples are taken at 0, 20, 40, 60, 90, 120, 150, 180, 200, 220, 250, 280 and 310 min at each of the three test days. Urine is collected over 310 min at each test day | No |
Other | Muscle protein breakdown, gene expression | Explorative parameter | 3 biopsies are taken at time 0, 150 min and 310 min. at each of the three test days | No |
Other | Metabolomics - urine and blood | Explorative parameter | Blood samples are taken at 0, 20, 40, 60, 90, 120, 150, 180, 200, 220, 250, 280 and 310 min at each of the three test days. Urine is collected over 310 min at each test day | No |
Primary | Change in Muscle protein synthesis (%FSR) | 3 biopsies are taken at time 0, 150 min and 310 min at each visit | No | |
Primary | Change in Muscle protein synthesis (%FSR) | 13 blood samples are taken over 310 min | No | |
Secondary | Visual analogue scales (10 cm) | Subjective appetite | Assessed at time 0, 160, 175, 200, 220, 250, 280, 310, 345 min at each of the three test days | No |
Secondary | Appetite - ad libitum energy intake | At 325 min an ad libitum meal of spaghetti bolognese is served, and the total energy intake is recorded | Measured once at time 325 min at each of the three test days | No |
Secondary | Postprandial response in glycemic control, plasma amino acids and appetite regulating hormones | Blood samples are taken at 0, 150, 180, 200, 220, 250, 280 and 310 min at each of the three test days | No |
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