| Eligibility |
Inclusion Criteria:
- Male or female
- Aged 18 to 40 years
- With a hint of Bodymass index (BMI) between 17 and 30 kg.m - 2
- healthy subject determined by a clinical examination, a psychological interview, a
blood test, a urine analysis
- Subject with a score<6 questionnaire PSQI ("Sleep Questionnaire Pittsburgh")
- Subject agreeing to maintain a regular sleep/wake rhythm during the study
- Subject agreeing to refrain from caffeine, nicotine, alcohol, psychotropic drugs,
cannabis or other drugs, during the study
- Signed informed consent
- Subjectaffiliated to a social protection scheme
Exclusion Criteria:
- somatic diseases: cardiovascular, respiratory, gastrointestinal, hematopoietic, Visual
- immune system diseases
- kidneys and urinary tract diseases
- endocrine and metabolic diseases
- neurological diseases
- infectious diseases
- thrombocytopenia or other malfunction of blood platelets
- Subject with risk of thrombosis, including subject with a history of phlebitis, smoker
under oral contraceptive...
- Subject with an addiction to caffeine, nicotine, alcohol, psychotropic drugs,
cannabis, or any other drug
- Subject treatment contraindicated or inadvisable in combination with heparin
- blood donation in the previous 3 months before the inclusion
- Participation in other clinical trials
- Work by shifts in the year preceding the inclusion
- Trans-meridian travel (> 2 time zones) in the month previous the inclusion
- Impossibility to give enlightened information (subject in an emergency situation,
understanding difficulties,...)
- Subject under safeguard of justice
- Subject under tutorship or curatorship
- Pregnancy (women of childbearing age)
- Breastfeeding
- Diet incompatible with the study's snack choices
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