HPV Specific Immune Lymphocytes (HPV-CTLs) in the Treatment of HPV

Status Recruiting

Clinical Trial Summary

The purpose of this clinical trial is to evaluate the safety and efficacy of IV-infused autologous or allogenic HPV-CTLs.

Clinical Trial Description

Human papilloma viruses (HPV) have been consistently implicated in causing cervical cancer especially those high-risk types (HPV 16, 18, 31, 45). Around 50-80% of women are infected by HPV within their whole lives. The current treatment of HPV-positive mainly includes drug, cryotherapy, laser, microwave, surgery and so on. Some treatments are convenient, but easy to cause pain or infection and there is still a greater risk of recurrence after treatment.

Adoptive immunotherapy with cytotoxic T lymphocytes (CTLs) reactive with specific viral antigens has proven to be effective. Here, the investigators aim to evaluate the safety and efficacy of multiple infusions of HPV specific cytotoxic T lymphocytes cells in patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03351855
Study type	Interventional
Source	Shenzhen Geno-Immune Medical Institute
Contact	Lung-Ji Chang, PhD
Phone	86-075586725195
Email	c@szgimi.org
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	November 15, 2017
Completion date	December 31, 2021

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