Human Milk Clinical Trial
Official title:
Effect of Different Tube-feeding Techniques on the Delivery of Human Milk Long-chain Polyunsaturated Fatty Acids
NCT number | NCT03459209 |
Other study ID # | SO-2017-LCPUFA |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | April 1, 2016 |
Est. completion date | April 30, 2017 |
Verified date | May 2019 |
Source | Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic (DHA) arachidonic acid (AA)
are major building blocks for the lipid bilayer of neuronal and retinal membranes and play a
crucial role in brain and visual development. Humans lack enzymes synthetizing DHA and AA
precursors and thus rely upon dietary sources to achieve adequate intakes. Human milk (HM)
feeding, either own mother's milk (OMM) or donor milk (DM), is the first nutritional choice
for preterm infants and provides appropriate LCPUFAs amounts to support neurological and
visual development of this fragile population.
Due to their immaturity, preterm infants are often unable to coordinate sucking and
swallowing, thus requiring tube feeding (TF) for prolonged time periods. During TF, fatty
acids tend to separate from aqueous milk components and to adhere to the infusion set, thus
reducing the delivery of HM lipid contents. To dare, however, a targeted evaluation of
TF-related LCPUFAs losses has not been performed.
This study aims to quantitatively assess, by means of gas chromatography coupled to mass
spectrometry, the effect of bolus and different continuous feeding methods routinely adopted
for preterm infants' enteral nutrition on the delivery of DHA and AA contained in human milk
samples.
Status | Completed |
Enrollment | 10 |
Est. completion date | April 30, 2017 |
Est. primary completion date | March 31, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Availability of breast milk - Stage of lactation: between 2 to 3 months after delivery - Written, informed consent obtained Exclusion Criteria: - breast milk not available - <2 months or >3 months from delivery - no consent obtained |
Country | Name | City | State |
---|---|---|---|
Italy | Neonatal Intensive Care Unit, S.Orsola-Malpighi Hospital | Bologna |
Lead Sponsor | Collaborator |
---|---|
Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | LCPUFA loss | Reduction in DHA and/or AA contents of each human milk aliquot after tube feeding administration | 3 hours |
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