Clinical Trials Logo
  1. Home
  2. Human Microbiome
  3. NCT04222699

Cultures Before and After Decolonization in Community Dwelling Adults With Current S. Aureus Colonization

Human Microbiome Clinical Trial

Official title:
Cultures Before and After Decolonization in Community Dwelling Adults With Current S. Aureus Colonization

Clinical Trial Summary

The investigators propose to study the microbiome of the nose, throat and three skin sites in a population without current exposure to the healthcare environment: 80 community dwelling adults. We will characterize the microbial communities in these body sites (nose, throat, perirectal and three skin sites) over time using culture-independent techniques. The investigators will then "decolonize" the subjects. Subjects will receive intranasal mupirocin and topical chlorhexidine. The investigators will then compare the microbial communities at baseline and after decolonization within individuals. Our overall hypothesis is that the microbial composition of these sites and the response to decolonization is influenced by the healthcare environment and that decolonization leads to re-colonization with an increasing proportion of Gram-negative bacilli.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04222699
Study type Interventional
Source VA Office of Research and Development
Contact
Status Completed
Phase Phase 4
Start date September 18, 2012
Completion date November 18, 2014
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05560087 - Association of PeRiODontal Disease and gUt Microbiome With Coronary artEry Disease (PRODUCE Study)
Completed NCT02392182 - Lung HIV Microbiome Project (Michigan Site) N/A
Completed NCT04597502 - The Effects of Terminalia Chebula Fruit Extract on the Gut Microbiome and Skin Biophysical Properties N/A
Completed NCT04596722 - Oral Pomegranate Extract on the Microbiome and Skin Biophysical Properties N/A
Completed NCT02731976 - Microbiome Composition Changes on 4 Week Gluten-free Diet Challenge N/A
Completed NCT05150184 - Isolation and Characterization of Multiple Microbial Species From Diverse Healthy Adults
Recruiting NCT03942159 - Modification of the Human Colon and Oral Microbiome by Allogenic HSCT
Completed NCT04335526 - A Clinical Study to Assess the Effect of Change of Bile Acid on the PD and Safety of Metformin and Microbiome Profiles Phase 1
Completed NCT03668015 - Xylitol and Sorbitol Effects on the Oral Microbiome N/A
Completed NCT03157687 - Detection of Luminal and Mucosa-associated Microbiome in Healthy Controls vs. Local and Systemic Inflammation
Not yet recruiting NCT04841694 - Oral Probiotics on the Shift in Gut Microbiome and Skin Carotenoid Levels N/A
Enrolling by invitation NCT03231332 - Effects of H.Pylori Eradication on Microbiome Phase 4
Completed NCT03181269 - Human Milk and Infant Intestinal Microbiome Study N/A
Completed NCT03543605 - Clinical/Microbiological Impact of a Specific Antimicrobial Stewardship Program for Nursing Homes N/A
Completed NCT01496898 - Changes in Vaginal, Cervical and Uterine Microflora With Levonorgestrel Intrauterine Device Placement N/A
Terminated NCT03907501 - Effects of Triphala and VSL#3 Probiotic Supplementation on Stool Microbiome Profiles and Inflammation N/A
Completed NCT03809260 - A Clinical Trial for Analysis of Intestinal Microbiome Affecting PK, PD, and Safety of Metformin N/A
Completed NCT04218799 - Human Microbiome and Healthcare Associated Infections - Nursing Home Dwelling Older Veterans Phase 4
Completed NCT03581812 - Snack Foods and Their Impact on Gastrointestinal Microbiology, Function and Symptoms N/A
Withdrawn NCT02407184 - Potential Restoration of the Infant Microbiome N/A