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Human Energy Expenditure clinical trials

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

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NCT ID: NCT01938794 Completed - Clinical trials for Human Energy Expenditure

A New Approach to Measuring Energy Expenditure in Humans

Start date: September 2013
Phase:
Study type: Observational

Accurately measuring how many calories a person burns each day is difficult to do. Researchers can do this with a technique called doubly labeled water (DLW). This involves drinking water that is "labeled" with a non-radioactive tracer. After a few hours, the labeled water can be detected in the urine. To measure how many calories are burned (Total daily energy expenditure, TDEE), urine samples are collected several days apart. Although this technique is accurate, it is also challenging for two reasons. First, the labeled water is expensive. Second, the urine samples are analyzed using equipment (Isotope Ratio Mass Spectrometer, or IRMS) that is expensive and difficult to operate. The goal of this project is to develop a new instrument to perform DLW measurements of TDEE. This instrument, called a triple isotope water analyzer (TIWA) is less expensive and easier to operate than IRMS. Additionally, since the TIWA is more accurate than IRMS, it may potentially reduce the amount of labeled water required to measure TDEE, and thus reduce costs. The purpose of this study is to compare the accuracy of measuring TDEE from labeled water using the new instrument (TIWA) and from the traditional approach (IRMS). We will also compare the accuracy to the measurement of TDEE from whole-room indirect calorimetry (metabolic room), which is considered the most accurate way to measure TDEE.