Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia

Human Endotoxaemia Clinical Trial

Official title: Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia

Status Completed

Clinical Trial Summary

This is a double blinded, randomised, crossover study with 12 healthy men between 18 and 40 year. The design is based on 6 days:

• day 1: On day time administration of LPS.

• day 2: On night time administration of LPS.

• day 3: On day time administration of LPS + Placebo.

• day 4: On day time administration of LPS + melatonin.

• day 5: On night time administration of LPS + placebo.

• day 6: On night time administration og LPS + melatonin.

Measuring the inflammatoric and oxidative response of LPS and the effect of melatonin compared to placebo on the endotoxaemia.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Endotoxemia
• Human Endotoxaemia

• NCT number: NCT01087359
• Study type: Interventional
• Source: Herlev Hospital
• Status: Completed
• Phase: Phase 4
• Start date: June 2010
• Completion date: February 2011