HPV Infection Clinical Trial
Human papillomavirus (HPV) infection is a worldwide problem strictly linked to the
development of cervical cancer. Persistence of the infection is one of the main factors
responsible for the invasive progression and women diagnosed with intraepithelial squamous
lesions are referred for further assessment and surgical treatments which are prone to
complications. Despite this, there are several reports on the spontaneous regression of the
infection.
In this study the investigators will evaluate the effectiveness of a long term
polyhexamethylene biguanide (PHMB)-based local treatment in improve the viral clearance
reducing the time exposure to the infection and avoiding the complications associated with
the invasive treatments currently available.
Women diagnosed with HPV infection were randomly assigned to receive six months of treatment
with a PHMB-based gynaecological solution (Monogin®) or to remain untreated for the same
period of time.
The administration of Monogin® has been performed every three days for fifteen days and then
every fifteen days for the subsequent six months.
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