House Dust Mite Allergy Clinical Trial
Official title:
Epigenetic Regulation of Excercise Induced Asthma
The purpose of this study is to investigate the micro ribonucleic acid (mRNA) profiles of patients with EIA without allergic sensitization and EIA with house dust mite sensitization compared to that of healthy controls.
Patients with known EIA are periodically reexamined by medical history, clinical examination, bodyplethysmography, spirometry, exhaled nitric oxide (eNO), skin prick test, methacholin challenge test and exercise-challenge in a cold-chamber at 2-4°C (ECC). Additionally the investigators gathers the questionnaires: Asthma Control Test (ACT) and Dyspnoe Index (DI). Besides these standard procedures the investigators want to investigate the micro-RNA profiles in two EIA subgroups: EIA with house-dust allergy (n = 24) and EIA without house-dust allergy (n = 24). Both groups are characterized by different eNO levels. The patients with EIA and house-dust allergy should have an eNO > 30 ppb, the patients with EIA without house-dust allergy an eNO < 20 ppb. The micro-RNA profiles of the both EIA subgroups will be compared the micro RNA profiles of 20 healthy controls . Therefore blood will be taken (for a complete blood count and micro RNA analysis) at three points of time: before ECC, directly after ECC and after 24 hours ± 4 hours after ECC. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02443805 -
Efficacy & Safety of STG320 Sublingual Tablets of HDM Allergen Extracts in Adults and Adolescents With HDM-associated AR
|
Phase 3 | |
Completed |
NCT03094845 -
Safety and Clinical Tolerability of hdmASIT+TM Peptides Administered in HDM-induced Allergic Patients
|
Phase 2 | |
Completed |
NCT01923792 -
ToleroMune House Dust Mite Follow on Study
|
N/A | |
Completed |
NCT01930461 -
Dose Ranging Study of SLIT Tablets of House Dust Mite Allergen Extracts (HDM) in Adults With HDM-associated Allergic Asthma
|
Phase 2 | |
Completed |
NCT00574704 -
A Study to Investigate an Immunomodulatory Therapy in Adult Patients With Perennial Allergic Rhinoconjunctivitis
|
Phase 2 | |
Completed |
NCT00263549 -
Safety and Efficacy of House Dust Mite Allergen Extract in the Treatment of Allergic Rhinoconjunctivitis
|
Phase 4 | |
Completed |
NCT05019209 -
Skin Responses and T Cell Immunology After House Dust Mite Exposure in Sensitized Atopic Dermatitis Patients
|
N/A | |
Recruiting |
NCT02238353 -
AZELASTINE/FLUTICASONE (AZE/FLU) Nasal Spray on Symptom Control, Nasal Mediators and Nasal Hyperresponsiveness in Allergic Rhinitis (AR)
|
Phase 4 | |
Completed |
NCT01454544 -
A One Year Trial Evaluating the Safety and Efficacy of the ALK House Dust Mite Allergy Tablet
|
Phase 3 | |
Terminated |
NCT01777464 -
Role of the Central Nervous System in Allergic Rhinitis
|
N/A | |
Completed |
NCT00574223 -
A Study to Investigate an Immunomodulatory Therapy in Adult Patients With Perennial Allergic Rhinoconjunctivitis
|
Phase 2 | |
Completed |
NCT02345278 -
SUBLIVAC FIX Mite Mixture Dose Tolerability Study
|
Phase 1/Phase 2 | |
Completed |
NCT01608243 -
Safety Study of Sublingual Immunotherapy Tablets of House Dust Mite Allergen Extracts
|
Phase 1 | |
Completed |
NCT04435678 -
Diagnostic Accuracy of the MADx Multi Array Xplorer (MAX 45k) Automated Laboratory System and the MADx Allergy Explorer Version 2 (ALEX²) - IgE Multiplex Test for the Diagnosis of Pre-defined Groups of Specific High-priority Allergens
|
N/A | |
Completed |
NCT01134757 -
Safety of Bronchial Allergen Challenge and Predictors for Positive Reaction.
|
N/A | |
Recruiting |
NCT05395689 -
Efficacy and Safety Assessment of Beltavac® With Polymerized Extract of HDM
|
Phase 3 | |
Not yet recruiting |
NCT05400811 -
Efficacy and Safety Evaluation for the Treatment of HDM Induced Allergic Asthma and Rhinitis/Rhinoconjunctivitis
|
Phase 3 | |
Not yet recruiting |
NCT05450289 -
The Efficacy of Nigella Sativa in Children With House Dust Mite-Induced Respiratory Allergy Receiving Immunotherapy
|
N/A | |
Terminated |
NCT04874714 -
Efficacy and Safety Evaluation for the Treatment of Asthma and Allergic Rhinitis/Rhinoconjunctivitis
|
Phase 3 | |
Completed |
NCT00380926 -
Fish Oil and Asthma in House Dust Mite Allergy
|
Phase 2/Phase 3 |