Clinical Trials Logo

Clinical Trial Summary

Hospital-acquired infections (HAIs) are significant public health issues, especially in low- and middle-income countries (LMICs). Hand hygiene and low-level disinfection of equipment (LLDE) practices among healthcare workers (HCWs) are essential to reduce HAIs. Various effective infection prevention and control (IPC) interventions to reduce HAI incidence have been developed. However, which interventions work effectively in LMICs has not been identified. The investigators aim to develop, pilot, and assess the feasibility and acceptability of an IPC intervention in Cambodia and the Lao People's Democratic Republic (PDR).


Clinical Trial Description

This study consists of four phases guided by the Medical Research Council (MRC) framework. Three hospitals from each country will be selected. In Phase 1, the investigators will conduct a gap analysis of IPC implementation and practices among HCWs at each hospital through desk review, direct observation of hand hygiene and LLDE practices, in-depth interviews with HCWs, and key informant interviews with stakeholders. In Phase 2, the investigators will develop an IPC intervention based on results from Phase 1 and interventions selected from the literature review of IPC interventions in LMICs. In Phase 3, the investigators will pilot the developed intervention in the same hospitals selected in Phase 1. Finally, in Phase 4, the investigators will assess the feasibility and acceptability of the developed intervention among HCWs and stakeholders at the selected hospitals. The investigators will employ the MRC framework to develop and evaluate an intervention to reduce HAIs in both countries. The investigators will also use a theoretical framework to explore factors that are barriers and enablers for HCWs to improve hand hygiene compliance. With these approaches, the investigators will be able to develop a comprehensive intervention. Findings from this study would shed light on promising IPC interventions to reduce HAI incidence in Cambodia and Lao PDR. More importantly, the findings may be applied to other LMIC settings. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05547373
Study type Interventional
Source National University of Singapore
Contact Sreymom Oy, MSc
Phone +85511867468
Email smomoy@nus.edu.sg
Status Recruiting
Phase N/A
Start date April 1, 2023
Completion date December 31, 2024

See also
  Status Clinical Trial Phase
Completed NCT00170560 - Impact of Gender on Patients
Completed NCT03411538 - Mortality Related to AMR in Patients With Hospital-acquired Infection
Not yet recruiting NCT05201560 - Efficacy and Safety of Butorphanol Tartrate Injection for the Patients With Mechanical Ventilation N/A