Horton's Disease Clinical Trial
Official title:
Study of Phenotypic and Functional Characteristics of Regulatory T Lymphocytes in Giant Cell Arteritis (Horton's Disease)
Giant cell arteritis (GCA) is the most frequent vascularitis after 50 years of age The
investigators recently showed that GCA was accompanied by an elevation in Th1 and Th17
response [1]. Even though a quantitative deficit in regulatory TL (Treg) was shown, there are
to date no data concerning their precise phenotypic and functional characteristics and
notably their ability to inhibit Th1 and Th17 polarisation. The hypothesis of the
investigator is that, in GCA, there is quantitative and above all functional deficit of Treg.
Recently, progress has been made in the identification of Treg with new markers (CD39), which
will make it possible to better identify and to study their specific functions. In this study
the phenotypic and functional characteristics of Treg in GCA will be analysed. Better
understanding of the role des Treg in GCA should lead to better-targeted treatments for
patients with GCA, notably via the blockage of cytokines that inhibit the differentiation
and/or function of Treg.
The study is classified interventional because a lot of blood samples are taken.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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| Completed |
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| Terminated |
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