Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function

Hookah Smoking Clinical Trial

Official title:

Effects of Hookah Smoking on Vascular Regulation: Novel Insight Into Endothelial Function

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03616002
• Other study ID #: Pro00036547
• Status: Terminated
• Phase: N/A
• Start date: January 1, 2015
• Est. completion date: March 2020

Study information

• Verified date: February 2021
• Source: Cedars-Sinai Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in the inner lining of the body's blood vessels.

Description:

The investigators will measure acute endothelial and vascular changes before and after a 30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and aortic pressure waveform measured by pulse tonometry.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 58
• Est. completion date: March 2020
• Est. primary completion date: March 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 29 Years

Eligibility

Inclusion Criteria:

• 18 to 29 years of age

• Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12 months

• Have not smoked cigarettes within the past 12 months

Exclusion Criteria:

• History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease

• Exhaled carbon monoxide level >10 ppm

• BP < 140/90 mmHg

• BMI <18.5 or > 30 kg•m2

• Resting heart rate > 100 beats/min

• Taking prescription medication

• History of illicit drug use

• Pregnant

Related Conditions & MeSH terms

• Hookah Smoking

Intervention

Other:
• Hookah smoking
ad lib hookah smoking for 30 minutes in a controlled laboratory environment.

Locations

Country	Name	City	State
United States	Cedars-Sinai Medical Center	Los Angeles	California

Sponsors (3)

Lead Sponsor	Collaborator
Cedars-Sinai Medical Center	University of California, Los Angeles, University of California, San Francisco

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Pulse wave velocity		change from baseline to immediately after smoking
Other	aortic pressure waveform		change from baseline to immediately after smoking
Primary	Brachial artery flow-mediated dilation		change from baseline to immediately after smoking
Secondary	Reactive hyperemia peripheral arterial tonometry		change from baseline to immediately after smoking