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Brentuximab Vedotin as Alternative to the Autologous Stem Cell Transplantation in Relapsed and Refractory Classical Hodgkin's Lymphoma (BASALT) — BASALT  

Hodgkin's Lymphoma Clinical Trial

Official title:
Brentuximab Vedotin as Alternative to the Autologous Stem Cell Transplantation in Relapsed and Refractory Classical Hodgkin's Lymphoma (BASALT)

Clinical Trial Summary

This study evaluate possibility of brentuximab vedotin, administered after first treatment failure (no response or relapse after I line therapy) of Hodgkin's lymphoma, to induce durable response or cure without autologous stem cell transplantation.

Clinical Trial Description

Brentuximab vedotin (BV) can induce durable response or cure in some patients with relapsed or refractory Hodgkin's lymphoma (RR HL) after autologous stem cell transplantation (ASCT) failure. It is expecting that BV alone administered earlier (after first treatment failure, without any additional treatment) can cure some RR HL patients and spare them from ASCT-associated risks and toxicity. Therefore in this study full course of BV which confirmed its curative potential in post-ASCT setting will be applicated to the potentially transplant-eligible RR HL patients immediately after first treatment failure, with a aim to assess curative potential of BV in this setting. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03474133
Study type Interventional
Source Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Contact Nikolay Zhukov, MD, PhD
Phone +7(926)4177766
Email 1cancerdoctor1@gmail.com
Status Recruiting
Phase Phase 2
Start date May 14, 2019
Completion date December 2, 2023
View Details
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