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Clinical Trial Details — Status: Terminated

Administrative data

NCT number NCT03495713
Other study ID # UPCC 04418
Secondary ID
Status Terminated
Phase Phase 2
First received
Last updated
Start date November 2, 2018
Est. completion date April 20, 2022

Study information

Verified date December 2023
Source Abramson Cancer Center at Penn Medicine
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This is a Phase II single-arm, single-site, open label clinical trial with r/r HL patients, aimed to determine whether a RadVax approach using low-dose RT added to nivolumab can improve response among patients who do not achieve a CR to nivolumab alone. The long-term goal is to develop an effective regimen for r/r HL patients.


Description:

Nivolumab 3 mg/kg will be administered on day 1 (pre-response assessment week 0) and on day 1 and continued per standard of care and institutional practices. At the week 1 biomarker collection, research FDG PET/CT will be performed to assess for FDG "flare." At week 8-12, PET/CT will be performed for the first response assessment. If a complete anatomic response is seen, nivolumab monotherapy will be continued on day 1 and continued per standard of care and institutional practices. By contrast, if at week 8 less than a complete anatomic response is seen, radiotherapy to 4 Gy x 2 fractions will be administered (post-response assessment week 0). The patient will be evaluated by a radiation oncologist while on treatment, and toxicities will be recorded. Nivolumab will be continued on day 1 and continued per standard of care and institutional practices. In either scenario, a second response assessment will be conducted ~8-12 weeks after the first response assessment. In either scenario, nivolumab monotherapy will be continued at the discretion of the treating medical oncologist. If there is less than CR post-RT and there is an additional untreated non-target lesion that can be followed, radiotherapy can again be administered when disease progresses to a previously untreated lesion, after which the patient will continue on the post-RT follow-up algorithm.


Recruitment information / eligibility

Status Terminated
Enrollment 7
Est. completion date April 20, 2022
Est. primary completion date April 20, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Pathologically confirmed Hodgkin lymphoma for whom nivolumab is clinically indicated. - Relapsed/refractory disease. - =2 sites of measurable disease, at least one outside of intended RT fields. - Age = 18 years. - ECOG performance status of 0-2. - Standard laboratory criteria for hematologic, and biochemical, and urinary indices within a range that, in the opinion of the physician, clinically supports enrollment of the subject on the trial. - Patients of reproductive potential must agree to use an effective contraceptive method during participation in this trial. - Ability to provide written informed consent. Exclusion Criteria: - Subjects with contraindications to immune checkpoint therapy, as follows: - Interstitial lung disease that is symptomatic or may interfere with the detection and management of suspected drug-related pulmonary toxicity. - Prior organ allograft or allogeneic bone marrow transplantation. - Subjects with contraindications to immune checkpoint therapy, as follows: - Interstitial lung disease that is symptomatic or may interfere with the detection and management of suspected drug-related pulmonary toxicity. - Prior organ allograft or allogeneic bone marrow transplantation. - Pre-existing thyroid abnormality with thyroid function that cannot be maintained in the normal range with medication. - Active autoimmune disease, except for vitiligo, type 1 diabetes mellitus, asthma, atopic dermatitis, or endocrinopathies manageable by hormone replacement; other autoimmune conditions may be allowable at the discretion of the principal investigator. - Condition requiring systemic treatment with either corticosteroids. - Systemic steroids at physiologic doses (equivalent to dose of oral prednisone 10 mg) are permitted. Steroids as anti-emetics for chemotherapy are strongly discouraged - Intranasal, inhaled, topical, intra-articular, and ocular corticosteroids with minimal systemic absorption are permitted. - Pregnant women, women planning to become pregnant and women that are nursing.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Nivolumab
Nivolumab 3 mg/kg will be administered on day 1 (pre-response assessment week 0) and on day 1 and continued per standard of care and institutional practices. A

Locations

Country Name City State
United States Abramson Cancer Center of the University of Pennsylvania Philadelphia Pennsylvania

Sponsors (1)

Lead Sponsor Collaborator
Abramson Cancer Center at Penn Medicine

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Complete Response Rate Overall complete response rate as determined by re-staging scan 25 weeks
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