Hodgkin Lymphoma Clinical Trial
Official title:
Dose-dense ABVD as First Line Therapy in Early Stage Unfavorable Hodgkin's Lymphoma: a Phase II, Prospective, Multi-center Study
Prospective, multicenter, Phase II trial designed to assess whether intensification of ABVD (dd-ABVD) is feasible and can improve the outcome of patients with early stage Hodgkin Lymphoma.
Dose-density has been shown to be an important factor for complete remission rate and
longterm survival in lymphomas.
The aims of this study were to find out whether intensification of ABVD (dd-ABVD) is feasible
and can improve the outcome of patients with early stage Hodgkin Lymphoma. In view of
emerging data on the role of early PET in defining prognosis in Hodgkin Lymphoma patients,
the percentage of FDG-PET (fluorodeoxyglucose positron emission tomography) negativity after
two cycle was chosen as the parameter to evaluate dd-ABVD activity.
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