Hodgkin Lymphoma Clinical Trial
Official title:
Early Chemotherapy Intensification With BEACOPP in High-risk, Interim-PET Positive Advanced-stage Hodgkin Lymphoma:a GITIL Retrospective Multicenter Clinical Study
Early interim-PET after two courses of chemotherapy is a powerful outcome predictor in
advanced-stage Hodgkin Lymphoma (HL) patients treated with adriamycin (doxorubicin),
bleomycin, vinblastine and dacarbazine (ABVD). Two-year Progression Free Survival of PET-2
positive patients is only 12%, but the optimal treatment for this patient subset is still
unknown.
From January 2006 GITIL (Gruppo Italiano Terapie Innovative nei Linfomi) suggested an early
intensification of chemotherapy with BEACOPP [Bleomycin, Etoposide, Adriamycin
(doxorubicin), Cyclophosphamide, Oncovin (vincristine), Procarbazine, and Prednisone](4
escalated + 4 baseline cycles) for all the HL patients with a positive PET-2 after 2 ABVD
courses. The investigators retrospectively recorded and analyzed these data in order to
evaluate if this strategy could be of benefit for this subset of patients.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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