Cognitive Remediation for Neuropsychological Impairment in Compulsive Hoarding

Hoarding Disorder Clinical Trial

Official title:

Cognitive Remediation for Neuropsychological Impairment in Compulsive Hoarding

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01451697
• Other study ID #: DIMA003472HI
• Status: Completed
• Phase: Early Phase 1
• Start date: July 2011
• Est. completion date: October 2012

Study information

• Verified date: May 2019
• Source: Hartford Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The primary aim of this pilot randomized controlled trial is to examine whether cognitive remediation, compared to a placebo, improves attention and related cognitive functions in patients with compulsive hoarding. The primary hypothesis is that compulsive hoarding patients who are treated with cognitive remediation will demonstrate improved cognitive skills at post-treatment compared to patients receiving placebo. This will be especially true of attention; memory and executive function skills may also be improved.

Description:

The primary aim of this pilot randomized controlled trial is to examine whether cognitive remediation, compared to a placebo, improves attention and related cognitive functions in patients with compulsive hoarding. Previous research has demonstrated that hoarders have diminished neuropsychological abilities, particularly in the areas of attention, memory, and executive function; and that cognitive remediation improves those functions in populations that are similarly impaired, such as in individuals with schizophrenia. The investigators will thus randomize 20 patients with compulsive hoarding to receive either cognitive remediation or a placebo condition. Before and after treatment, the investigators aim to assess the effects of cognitive remediation on neuropsychological functioning and hoarding severity. The primary specific aim is to examine whether cognitive remediation improves cognitive function in compulsive hoarders. The investigators hypothesize that compulsive hoarding patients who are treated with cognitive remediation will demonstrate improved cognitive skills at post-treatment compared to patients receiving placebo. This will be especially true of attention; memory and executive function skills may also be improved. A secondary, exploratory aim is to examine whether cognitive remediation improves hoarding severity, compared to placebo. The ultimate goal of this research is to determine the feasibility and appropriateness of pursuing larger-scale studies of the promising new approach of combining cognitive remediation with other treatments for compulsive hoarding—particularly cognitive-behavioral therapy (CBT).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: October 2012
• Est. primary completion date: July 2012
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• be over 18 years of age,

• have a current primary diagnosis of hoarding disorder

• have no untreated and/or unstable concurrent psychiatric diagnoses

• have a score on the ADHDSS that is one standard deviation or more above the mean

• have an Attentional Composite score on the computerized battery of neuropsychological tests (Doniger, 2010) that is one standard deviation or more below the mean

• be stable on all psychotropic medications during and up to four weeks preceding enrollment in the study

Exclusion Criteria:

• currently taking any cognitive enhancers or stimulants

• people with a history of Multiple Sclerosis, Traumatic Brain Injury, loss of consciousness lasting more than 5 minutes, seizures, dementia, or other organic brain-related disorders

• current Alcohol or Substance Abuse and/or a history of Alcohol or Substance Dependence

Related Conditions & MeSH terms

• Attentional Impairment
• Hoarding Disorder

Intervention

Behavioral:
• Cognitive Remediation
A computerized cognitive remediation program focused on attentional training will be used.
• Control (Placebo)
The control condition will involve relaxation training.

Locations

Country	Name	City	State
United States	Anxiety Disorders Center, Institute of Living/Hartford	Hartford	Connecticut

Sponsors (1)

Lead Sponsor	Collaborator
Hartford Hospital

Country where clinical trial is conducted

United States, 

References & Publications (55)

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* Note: There are 55 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Continuous Performance Task (computerized version): change from Baseline in Attentional Functioning at 8 Weeks	This measure is a computerized assessment of attention, memory, and executive functioning. The investigators will use this measure to assess change in those cognitive domains between Baseline (Week 0) and Endpoint (Week 8).	Week 0 (Baseline) and Week 8 (Endpoint)