Botanical/Drug Interactions in HIV: Glucuronidation

Status Completed

Clinical Trial Summary

A series of clinical studies will be conducted in normal, healthy adult volunteers to evaluate the potential for alterations in the pharmacokinetics of anti HIV drugs when botanicals/nutriceuticals are given concurrently via the oral route. Both the drugs and botanicals are known to rely upon or to modulate, respectively, metabolism via glucuronidation.

Clinical Trial Description

As per Brief Summary ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

HIV Seronegativity

Clinical Trial Details

NCT number	NCT00065741
Study type	Interventional
Source	National Center for Complementary and Integrative Health (NCCIH)
Contact
Status	Completed
Phase	Phase 1
Start date	September 2003
Completion date	March 2006

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00056953` - Peer Mentors for Adolescents in HIV Affected Families	Phase 2
Completed	`NCT00047931` - HIV-1 Vaccine Test in Uninfected Adult Volunteers	Phase 1
Completed	`NCT03995862` - Evaluation of Pre-Exposure Prophylaxis Against HIV in Alpine Region
Completed	`NCT00006327` - Effectiveness of AIDSVAX B/E Vaccine in Intravenous Drug Users in Bangkok, Thailand	Phase 3
Completed	`NCT03086200` - Randomized Controlled Trial of iTAB Plus Motivational Interviewing for PrEP Adherence in Transgender Individuals	N/A
Completed	`NCT00076817` - Safety and Effectiveness of Administering an HIV Vaccine in the Groin Versus the Arm	Phase 1
Completed	`NCT03191474` - Linkage of Transgender Individuals to PrEP	N/A
Completed	`NCT00121121` - Safety of Intradermal Versus Intramuscular Administration of HIV Lipopeptides in HIV Uninfected Adult Volunteers	Phase 1
Completed	`NCT00009685` - HIV-1 Vaccine Test in Uninfected Adult Volunteers	Phase 1
Completed	`NCT00031304` - Screening Protocol for HIV Vaccine Studies
Completed	`NCT00055237` - Bevacizumab to Treat Kaposi's Sarcoma in HIV-Positive and HIV-Negative Patients	Phase 2
Completed	`NCT02125773` - Pre-exposure Prophylaxis Accessibility Research and Evaluation 2	N/A
Terminated	`NCT00789789` - Cohort Study of Volunteers That Have Participated to Preventive HIV-1 Vaccine Trials	N/A
Completed	`NCT01761643` - CCTG 595: Text Messaging Intervention to Improve Adherence to PrEP in High-risk MSM	Phase 4
Completed	`NCT01418235` - Safety of and Immune Response to a DNA HIV Vaccine Boosted With a Modified Vaccinia HIV Vaccine and Protein HIV Vaccine in Healthy Adults	Phase 1
Completed	`NCT00028119` - HIV Incidence and Participation Retention in Pune, India
Completed	`NCT00076232` - A Study of Acyclovir to Help Prevent HIV Infection in People With Genital Herpes	Phase 3
Completed	`NCT00004579` - A Study to See Whether Two HIV Vaccines Are Safe and Can Prevent HIV Infection	Phase 1
Active, not recruiting	`NCT00013572` - HIV Candidate Vaccine, ALVAC-HIV-1, Administration in HIV-Negative Adults	Phase 1
Completed	`NCT00002441` - Effectiveness of an HIV Vaccine in HIV-Negative Adults in North America Who Are at Risk of HIV Infection	Phase 3