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NCT ID: NCT01503255 Completed - Binge Drinking Clinical Trials

A Stage 2 Cognitive-behavioral Trial: Reduce Alcohol First in Kenya Intervention

RAFIKI
Start date: July 2012
Phase: Phase 1
Study type: Interventional

This study will determine whether a group cognitive-behavioral therapy intervention that demonstrates preliminary evidence of reducing alcohol use among HIV-infected outpatients in western Kenya is effective when compared against a group health education intervention in a large sample over a longer period of time. It will be delivered by paraprofessionals, individuals with limited formal education and little or no relevant professional experience. This approach is consistent with successful cost-effective models of service delivery in resource-limited settings in which paraprofessionals (e.g., clinical officers, traditional birth attendants and peer counselors) are trained.

NCT ID: NCT01394133 Withdrawn - HIV Infected Clinical Trials

Impact of Menstrual Cycle on Antiretroviral Pharmacokinetics in HIV-Infected Women

Start date: July 2011
Phase: N/A
Study type: Observational

Data suggests that women taking drugs to treat human immunodeficiency virus (HIV) have higher amounts of drugs in their body compared with men taking the same dose of anti-HIV drugs. The reason for this higher drug exposure has not yet been determined. The primary purpose of this study is to examine whether a pharmacokinetics (factors that determine the amount of drug in the body) of anti-HIV drugs change during different phases of the menstrual cycle in women and ultimately result in higher amounts of drug in the body compared with men. In other words, we plan to examine whether changes in sex hormones throughout the menstrual cycle affect the amount of anti-HIV drugs in HIV infected women. The antiretroviral drugs atazanavir, ritonavir, tenofovir and emtricitabine will be studied.