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Antiretroviral Treatment Guided by Proviral Genotype: Pilot Trial of Proof of Concept.

HIV-1-infection Clinical Trial

Official title:
Antiretroviral Treatment Guided by Proviral Genotype: Pilot Trial of Proof of Concept.

Clinical Trial Summary

Phase IIa, open clinical trial, pilot, single arm and proof of concept.

Clinical Trial Description

Proof of concept trial evaluating safety and efficacy of treatment with Dolutegravir (DTG) + lamivudine (3TC) once daily in suppressed participants with history of previous treatment with 3TC or emtricitabine (FTC). Half of the participants will have history of failure with 3TC or FTC and M184V/I or K65R/E/N mutations in previous plasma genotypes, although to be eligible these mutations cannot be detectable at study entry in proviral DNA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03539224
Study type Interventional
Source Instituto de Investigación Hospital Universitario La Paz
Contact
Status Active, not recruiting
Phase Phase 2
Start date November 2, 2017
Completion date July 31, 2021
View Details
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