Itch Sensation Induced by Multiple Applications of Pruritogens (Temporal Summation)

Histamine Clinical Trial

Official title: Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception

Status Not yet recruiting

Clinical Trial Summary

In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli. The hypothesis behind this study (temporal summation) is that two overlapped applications of pruritogens will result in a higher itch sensation compared with a single application.

Clinical Trial Description

Chronic itch affects approximately a fifth of the global population and is associated with substantial negative consequences for the affected individuals. Furthermore, there is a lack of efficient treatment options for chronic itch. In order to mimic a clinical itch condition as presented in patients, the aim of the project is to investigate a new itch model based on the multiple applications of pruritogens (temporal summation). In particular, the purpose is to evaluate if a single application of cowhage/histamine (non-histaminergic and histaminergic itch, respectively) results in a lower itch sensation compared with two overlapped applications of the pruritogens on the same area. ;

Related Conditions & MeSH terms

• Cowhage
• Histamine

• NCT number: NCT06328543
• Study type: Interventional
• Source: Aalborg University
• Contact: Silvia Lo Vecchio, PhD
• Phone: +4521397785
• Email: slv@hst.aau.dk
• Status: Not yet recruiting
• Phase: N/A
• Start date: July 1, 2024
• Completion date: December 31, 2026