The Role of Histamine in Muscle Protein Synthesis Following Resistance Training

Histamine Clinical Trial

Official title:

The Role of Histamine in Muscle Protein Synthesis Following Chronic Resistance Training

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06152497
• Other study ID #: MPSH - ONZ-2023-0027
• Status: Recruiting
• Phase: N/A
• Start date: September 1, 2023
• Est. completion date: December 31, 2026

Study information

• Verified date: December 2023
• Source: University Ghent
• Contact: Wim Derave, Professor
• Phone: 92646326
• Email: wim.derave[@]ugent.be
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: December 31, 2026
• Est. primary completion date: December 31, 2026
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Male

• 18-45 years

• Not to medium physically active

Exclusion Criteria:

• Smoking

• Chronic disease

• High blood pressure

• Supplement or medication intake

• Seasonal allergies

• Vegetarian / vegan

• Resistance trained

Related Conditions & MeSH terms

• Histamine

Intervention

Drug:
• Placebo
Oral placebo
• H1 blockade: Telfast: 180mg Fexofenadine
H1 blockade: oral blockade with 180mg Fexofenadine

Behavioral:
• Resistance training
Resistance training: lower body exercise

Locations

Country	Name	City	State
Belgium	Department of movement and sports sciences, Ghent University, Belgium	Ghent	Oost-Vlaanderen

Sponsors (2)

Lead Sponsor	Collaborator
University Ghent	Research Foundation Flanders

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle volume	Change in muscle volume	Before and after the 10 weeks of resistance training
Primary	Maximal dynamic strength of leg press, bench press, bicep curl and leg curl	Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl	Before and after the 10 weeks of resistance training
Primary	Muscle fiber hypertrophy in muscle biopsies	Change in muscle fiber hypertrophy in muscle biopsies	Before and after the 10 weeks of resistance training
Primary	Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)	Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)	Before and after the 10 weeks of resistance training
Primary	Vascular function measured with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)	Change in vascular function with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)	Before and after the 10 weeks of resistance training
Secondary	Blood pressure (systolic and diastolic)	Chance in Blood pressure (systolic and diastolic)	Before and after the 10 weeks of resistance training
Secondary	Resting heart rate	Chance in Resting heart rate	Before and after the 10 weeks of resistance training