Clinical Trials Logo

Clinical Trial Summary

The study is designed to determine if enhanced recovery after surgery (ERAS) principles could provide benefit for pediatric patients undergoing radical surgery for Hirschsprung's Disease (HD). Half of patients will receive the ERAS program, while the other half will receive the traditional program.


Clinical Trial Description

Optimized peri-operative care within an enhanced recovery after surgery (ERAS) protocol is designed to reduce morbidity after surgery, resulting in a shorter hospital stay. The present study evaluated this approach in the context of radical surgery for pediatric patients with Hirschsprung's Disease(HD). Patients undergoing radical surgery for HD will be enrolled in a randomized clinical trial comparing ERAS protocol vs a control group that received standard care. The primary outcome is median length of postoperative hospital stay. The second outcomes include postoperative complications rates,gastrointestinal function recovery time,mean cost per patient,readmission rates within postoperative 30 days,and the levels of stress and inflammation marker. ;


Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT02776176
Study type Interventional
Source Nanjing Children's Hospital
Contact Weibing Tang, MD&PhD
Phone +86 13851683700
Email twbcn@njmu.edu.cn
Status Recruiting
Phase N/A
Start date January 2016
Completion date December 2019

See also
  Status Clinical Trial Phase
Completed NCT00630838 - Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC) Phase 2
Not yet recruiting NCT03269812 - Laparoscopic Assisted Pull-through Versus Other Surgical Procedures for Treatment of Hirschsprung Disease N/A
Recruiting NCT02343562 - Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated Enterocolitis Phase 4
Completed NCT01985646 - A Trial on Conservative Treatment for Infants' Hirschsprung Disease Phase 0
Completed NCT01515501 - Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis, a Controlled Prospective Trial (EDGE Trial) N/A
Enrolling by invitation NCT04150120 - eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness N/A
Completed NCT03666767 - Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
Completed NCT04837963 - Does Hirschsprung Disease Increase the Risk of Febrile Urinary Tract Infection in Children
Recruiting NCT04149093 - The Association Between Calretinin and the Function of Ganglion Cells in Hirschsprung Disease
Recruiting NCT04622410 - Registry for Hirschsprung Disease of the BELAPS
Completed NCT04020939 - The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery. N/A
Completed NCT05038345 - Hirschsprung Disease Trends
Recruiting NCT06072976 - The Influence of Feeding Source on the Gut Microbiome and Time to Full Feeds in Neonates With Congenital Gastrointestinal Pathologies N/A
Recruiting NCT05293353 - Neokare Safety and Tolerability Assessment in Neonates With GI Problems
Completed NCT02857205 - MICROPRUNG : Intestinal Microbiota Analysis in Patients With or Without Hirschsprung's Associated EnteroColitis N/A
Recruiting NCT04904081 - Feasibility of Use of Indocyanine Green in Pediatric Colorectal Surgery Phase 3
Recruiting NCT01793168 - Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Completed NCT04730128 - Translation and Validation of a Disease-specific Questionnaire for Hirschsprung's Disease in Danish Patients
Recruiting NCT05450991 - Long-term Qualitative and Quantitative Outcomes of Children With Hirschsprung's Disease and Anorectal Malformations
Recruiting NCT02216994 - A New Scoring System Improves Diagnostic Accuracy of Intestinal Dysganglionosis --a Prospective Study N/A