Fluid and Nutrition in Elective Hip Surgery

Hip Surgery Corrective Clinical Trial

Official title:

Fluid and Nutrition in Elective Hip Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01211184
• Other study ID #: STS1
• Status: Completed
• Phase: N/A
• First received: September 28, 2010
• Last updated: June 28, 2013
• Start date: May 2008
• Est. completion date: December 2009

Study information

• Verified date: December 2011
• Source: Sodertalje Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Sweden: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether fluid or glucose administration before hip replacement surgery minimizes postoperative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism.

Description:

1. How can a simple and safe way to measure the body's tendency to transient diabetes associated with surgery?

2. Can fluid or glucose administration before elective hip surgery, minimizing post-operative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism?

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: December 2009
• Est. primary completion date: December 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria: Patient scheduled for hip surgery. Exclusion Criteria:

Endocrinological disorders.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Hip Surgery Corrective

Intervention

Dietary Supplement:
• Water administration
patients undergo hip surgery after receiving 800 ml water by mouth in the morning before the surgery.
• carbohydrate drink
800 ml carbohydrate drink by mouth the evening before surgery and 400 ml carbohydrate drink by mouth 2 hours before surgery

Behavioral:
• Fasting.
The patient is fasting from midnight before the surgery.

Locations

Country	Name	City	State
Sweden	Södertälje Hospital	Södertälje

Sponsors (1)

Lead Sponsor	Collaborator
Sodertalje Hospital

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Insulin Sensitivity (Percent)	Insulin sensitivity (micro-mol per kg per minute glucose uptake) was calculated based on an intravenous glucose tolerance test (Theor Biol Med Model 2011, 8: 12) on the day before surgery. The percent change was taken as (day after - day before) / day before	Day before surgery (approximately 3 PM) and in the morning after surgery (approx. 7.30 AM).	No
Secondary	Muscle Catabolism	Assessed by the ratio of 3-methylhistidine/creatinine in excreted urine (unit: mmol/mmol).This is an amino acid unique to muscle that does not undergo intermediary metabolism, meaning that its urinary excretion is an index of the degree of muscle catabolism.	From the morning after surgery (07.30) up to the morning two days after sthe surgery (07.30)	No