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NCT05446181 Clinical Trial

CLIC1 in Patients Presenting PD

Hip Fractures Clinical Trial

Official title:
Accumulation of Chloride Intracellular Channel 1 (CLIC1) Protein in Circulating Monocyte in Elderly Patients Presenting Postoperative Delirium and Its Predictable Role of Postoperative Delirium

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05446181
Other study ID # B-2109-706-302
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 27, 2022
Est. completion date June 30, 2023

Study information
Verified date August 2022
Source Seoul National University Bundang Hospital
Contact Hyo-Seok Na
Phone 82317877507
Email hsknana@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia. We then observe the accumulation of chloride intracellular channel 1 (CLIC1), particularly the characteristic accumulation morphology and its function. The purpose of this study is to compare whether there is a difference in the degree and form of cytoplasmic CLIC1 accumulation between the elderly group with postoperative delirium (PD) and the elderly group without postoperative delirium. We'll also confirm whether this is appropriate as a predictor of postoperative delirium. In addition, we will establish a control group for the non-elderly group to check the difference due to aging itself.

Recruitment information / eligibility
Status Recruiting
Enrollment 90
Est. completion date June 30, 2023
Est. primary completion date June 30, 2023
Accepts healthy volunteers No
Gender All
Age group 20 Years and older
Eligibility Inclusion Criteria: - Old group: Male or female patients aged 65 years or older who are scheduled to undergo surgery for an orthopedic hip fracture under spinal anesthesia - Young group: Male or female patients between 20 and 50 years of age who are scheduled to undergo orthopedic hip joint surgery under spinal anesthesia Exclusion Criteria: - Patients who are unconscious - Patients who are unable to communicate

Study Design

Related Conditions & MeSH terms

Intervention

Behavioral:
• Postoperative delirium
Postoperative delirium
Procedure:
• Hip surgery
Orthopedic hip joint surgery under spinal anesthesia

Locations
Country Name City State
Korea, Republic of Seoul National Univ. Bundang Hospital Seongnam Gyeonggi

Sponsors (1)
Lead Sponsor Collaborator
Seoul National University Bundang Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary expression pattern of CLIC1 protein Immediate after spinal anesthesia
See also
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