Application of New Magnetic Resonance UTE Technique in Hip Joint Lesions

Hip Disease Clinical Trial

Official title:

Application of New Magnetic Resonance Technique-UTE in Hip Joint Lesions

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05998720
• Other study ID #: ZDWY.FSK.025
• Status: Recruiting
• Start date: July 1, 2023
• Est. completion date: June 13, 2024

Study information

• Verified date: August 2023
• Source: Fifth Affiliated Hospital, Sun Yat-Sen University
• Contact: Xiaojun Chen
• Phone: +8615820587112
• Email: 422175400[@]qq.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Explore the imaging and quantitative monitoring of hip bone, cartilage and ligament by magnetic resonance UTE technology, combined with QCT and DXA technology, to provide a more accurate basis for clinical evaluation and treatment.

Description:

Osteoporosis is a systemic bone metabolism-related disease characterized by decreased bone mass per unit volume, increased bone fragility, decreased bone density, thinning of the bone cortex and changes in bone microstructure. It often occurs in the lumbar spine and hip joint. Femoral neck fracture is a common complication of hip osteoporosis, which seriously affects people's quality of life. UTE technology can clearly image and quantify human cortical bone and cancellous bone, and advanced UTE technology such as STAIR-UTE and UTE-MT have made some progress in the field of osteoporosis. The purpose of this study was to explore UTE technology for imaging and quantitative study of cortical bone, cancellous bone and cartilage of hip joint, and to find more accurate imaging methods for clinical evaluation of hip osteoporosis and other diseases.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 150
• Est. completion date: June 13, 2024
• Est. primary completion date: June 13, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

1. Patients with past or suspected osteoporosis and bone loss;

2. Patients with previous femoral neck fracture;

3. Patients with avascular necrosis of femoral head;

4. Hip osteoarthritis patients.

Exclusion Criteria:

1. Patients with metal implants in corresponding parts;

2. Claustrophobic.

Related Conditions & MeSH terms

• Hip Disease

Locations

Country	Name	City	State
China	Radiography department	Zhuhai	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Fifth Affiliated Hospital, Sun Yat-Sen University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	proton density fat fraction (PDFF)	Magnetic resonance proton density fat fraction	Baseline (before surgery)
Primary	T2 relaxation rate	R2*	Baseline (before surgery)
Primary	Magnetization Transfer Ratio (MTR)	magnetization transfer ratio	Baseline (before surgery)
Primary	T1rho	spin-lattice relaxation in the rotation ame	Baseline (before surgery)
Secondary	Subjective rating values	rating values	Baseline (before surgery)