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Hilar Lymphadenopathy clinical trials

View clinical trials related to Hilar Lymphadenopathy.

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NCT ID: NCT05535439 Completed - Clinical trials for Mediastinal Lymphadenopathy

Diagnostic Yield & Specimen Adequacy of Flex 19 G vs 22 G EBUS Needle - A Randomized Controlled Trial

EBUS-TBNA
Start date: September 15, 2022
Phase: N/A
Study type: Interventional

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the minimally invasive diagnostic modality for the evaluation of mediastinal and hilar lymph nodes (LNs). Traditionally, EBUS-TBNA is performed using either 21 gauge (G) or 22 G needle with a major limitation of inadequate sample especially when histologic assessment of tissue architecture is necessary such as in lympho-proliferative disorders and granulomatous inflammation. Although the specimen obtained with larger bore 19 G needle has been shown to be superior in terms of more cellular material and ability to subclassify malignant disease, it has more bloody samples. Recently a novel 22 G fine needle biopsy device (EBUS-FNB) has been introduced for endobronchial use after an experience gained from gastroenterology endoscopic ultrasound reporting high yield for core biopsies. FNB device has a unique design with 3 symmetrical, fully formed, cutting heels with 3 angled points to provide acquisition of FNB specimen in the form of a core tissue which might improve the overall diagnostic yield. Herein, investigators will study the diagnostic yield and safety of the 22 G EBUS-FNB needle with 19 G EBUS needle in the evaluation of mediastinal and hilar lymphadenopathy.

NCT ID: NCT05110950 Not yet recruiting - Lymphoma Clinical Trials

Endobronchial Ultrasound Needle Aspiration With and Without Suction

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

The main purpose of the present study is to compare the diagnostic yield of different aspiration techniques in Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) in the diagnosis of hilar/mediastinal adenopathy

NCT ID: NCT03172832 Terminated - Cholangiocarcinoma Clinical Trials

A Trial of Percutaneous vs. Endoscopic Drainage of Suspected Klatskin Tumors

INTERCPT
Start date: August 20, 2017
Phase: N/A
Study type: Interventional

The optimal approach to the drainage of malignant obstruction at the biliary hilum remains uncertain. This is a randomized comparative effectiveness study of percutaneous transhepatic biliary drainage (PTBD) vs. endoscopic retrograde cholangiography (ERC) as the first intervention in patients with cholestasis due to suspected malignant hilar obstruction.

NCT ID: NCT01658280 Completed - Lymphoma Clinical Trials

Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymphadenopathies

Start date: August 2012
Phase: Phase 4
Study type: Interventional

The main purpose of the present study is to assess whether the sensitivity of Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) is superior to that of conventional TBNA in the diagnosis of hilar/mediastinal adenopathy and lung cancer staging.

NCT ID: NCT01467635 Withdrawn - Lymphoma Clinical Trials

EBUS-TBNA Versus EBUS-TBNB

Start date: May 2014
Phase: N/A
Study type: Interventional

A prospective diagnostic clinical study randomising patients undergoing endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) of enlarged mediastinal and hilar lymph nodes to have sampling using the usual EBUS-TBNA needle or a novel biopsy forceps (EBUS-TBNB). The study aims to establish whether the use of EBUS-TBNB can significantly increase the diagnostic yield over EBUS-TBNA, without an increase in complication rates.