Upper-body High-intensity Interval Training and Mixed Meal Responses

High-Intensity Interval Training Clinical Trial

Official title:

The Effect of Upper-body High-intensity Interval Exercise vs. Moderate-intensity Continuous Exercise on Postprandial Metabolism

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04277091
• Other study ID #: EP 18/19 087
• Status: Completed
• Phase: N/A
• Start date: October 21, 2019
• Est. completion date: January 1, 2021

Study information

• Verified date: July 2022
• Source: University of Bath
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Cycling and running-based high-intensity interval training are well-established to improve a variety of health outcomes. However, the efficacy of upper-body high-intensity interval training, vital for individuals with lower-body impairments, has yet to be well-characterized. The purpose of this study is to compare the effect of a single bout of upper-body high-intensity interval exercise (HIIE) in comparison to traditional moderate-intensity continuous exercise (MICE) on the blood response (e.g. glucose, insulin, fats) following a meal.

This study is recruiting able-bodied adults (aged 18-65 years). Participants will need to attend the laboratory at the University of Bath for two preliminary sessions, and three main study trials.

Description:

The aim of this research is to determine the metabolic responses to a mixed-meal tolerance test following an acute bout of HIIE and an energy-matched MICE bout in able-bodied persons. The hypothesis is that HIIE and MICE will be more effective at reducing the total triglyceride responses compared to a resting control condition.

Preliminary measurements:

Preliminary testing will include measurements of weight and height. There will also be an assessment of resting metabolic rate and maximal exercise capacity. On a second visit, a HIIE familiarisation session will be performed to determine total energy expenditure of the session. All of the exercise protocols will take place on an arm crank ergometer at the University of Bath.

Main trial days:

Before all main trials, participants will be asked to refrain from performing any strenuous physical activity in the 48-h prior (i.e. day 0 and 1) and consuming alcohol/caffeine in the 24-h prior (i.e. day 1). On day 1, participants will be asked to record/replicate their diet using a weighed food-diary. Participants will be asked perform exercise (HIIE and MICE only) at 18:00 on day 1, having consumed no food (other than plain water) from 14:00. They will be given a standardised dinner to eat at 20:00, and asked to avoid the ingestion of any further food (other than plain water) for the rest of the evening.

On day 2 and upon arrival to the laboratory, a cannula will be inserted into a vein, and a baseline blood sample and expired air sample will be taken. The participant will then be asked to consume a smoothie, consisting of peanut butter, banana, coconut oil, sugar, and chocolate-flavoured whey protein powder. The meal should be consumed within 10 minutes and blood samples will be taken from the cannula at 15, 30, 45 60, and 90 minutes and then at every hour for 5 hours after consumption of the meal to monitor changes in metabolic markers. Expired gas samples will also be taken hourly and indirect calorimetry will be used to estimate relative fat and carbohydrate metabolism in response to the meal.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: January 1, 2021
• Est. primary completion date: January 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Non-smoker

• No history of cardiovascular, metabolic, or neuromuscular disease

Exclusion Criteria:

• Individuals with a nut allergy

Related Conditions & MeSH terms

• High-Intensity Interval Training

Intervention

Other:
• High-intensity interval training
Arm-cranking exercise
• Moderate-intensity continuos training
Arm-cranking exercise

Locations

Country	Name	City	State
United Kingdom	Department for Health	Bath

Sponsors (1)

Lead Sponsor	Collaborator
University of Bath

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postprandial triglyceride concentrations	Postprandial triglyceride concentrations in serum samples	5 hours
Secondary	Postprandial glucose concentrations	Postprandial glucose concentrations in serum samples	5 hours
Secondary	Postprandial insulin concentrations	Postprandial insulin concentrations in serum samples	5 hours
Secondary	Postprandial substrate oxidation	Postprandial substrate oxidation determined by indirect calorimetry	5 hours
Secondary	Rating of Perceived Exertion	Global, central, and local rating of perceived exertion (6-20) during exercise	HIIE: End of Warm-Up, 8 min, 12 min, 16 min, 20 min, 24 min. MICE: 0, 20, 40, 60, 80, 100% through exercise session (exact time points dependent on exercise time for each participant)
Secondary	Heart Rate	Heart rate during exercise	HIIE: End of Warm-Up, 8 min, 12 min, 16 min, 20 min, 24 min. MICE: 0, 20, 40, 60, 80, 100% through exercise session (exact time points dependent on exercise time for each participant)
Secondary	Affect	Affect measured through the Feeling Scale (FS) during exercise. FS is a one item scale ranging from +5 ("Very good") to -5 ("Very bad").	HIIE: End of Warm-Up, 8 min, 12 min, 16 min, 20 min, 24 min. MICE: 0, 20, 40, 60, 80, 100% through exercise session (exact time points dependent on exercise time for each participant)
Secondary	Exercise Enjoyment	Enjoyment measured by the Physical Activity Enjoyment Scale (PACES). PACES is a 17-item scale, with each item scored from 1 to 7. The total score will be calculated.	30 min post-exercise
Secondary	Self-efficacy	Confidence in ability to perform exercise performed during trial in the next 4 weeks measured using a 5-item scale ranging from 0% ("Not at all" to 100% ("Extremely confident").	30 min post-exercise