High-Intensity Interval Training Clinical Trial
Official title:
A Randomised Control Trial to Assess the Efficacy of Short-term, Home-based High- Intensity Interval Training (HIT) for Improving Indices of Cardiorespiratory Fitness
This study will aim to evaluate the efficacy of a short-term, home-based, high-intensity
interval (HIT) programme in improving cardiovascular fitness in healthy volunteers aged 55
and above, with an age-comparison to younger individuals taking part in the same training
regime.
It will also explore the efficacy of time-matched 'static' interventions for improving
cardiovascular parameters in middle-aged females and older adults.
Patients with lower peak oxygen uptake have higher mortality and morbidity when undergoing
major surgery. Aerobic fitness is a potentially modifiable risk factor for postoperative
complications.
Traditional pre-operative exercise interventions to improve fitness involve high time and
supervision-demands, often resulting in poor compliance. High-intensity interval training
(HIT) is a time-efficient, feasible method to improve pre-operative fitness, however current
studies only involve exercise in the laboratory setting.
Study Design Thirty-six healthy volunteers aged 55y and over will be randomly allocated to
one of three groups: 1) Laboratory-HIT; 2) Home-HIT; 3) No intervention. All HIT sessions
will involve a brief warm-up, followed by five 1-minute bouts of high-intensity (body-weight
based) exercise, interspersed with 90-seconds recovery, concluding with a brief cool-down.
The primary endpoint of the study is change in VO2 peak with secondary endpoints of changes
in: anaerobic threshold, insulin sensitivity and muscle mass.
Subjects will be expected to perform up to a maximum of 16 HIT sessions (maximum 5 sessions
per week) within a period of 31 days. Aerobic fitness will be assessed prior to and following
the exercise, as will body composition, muscle structure, physical function and insulin
sensitivity.
For the age comparison, 24 young individuals will be recruited to either a control or
home-HIT arm.
In addition, the efficacy of time-matched 'static' interventions for improving cardiovascular
parameters in 24 middle-aged females will also be assessed as exploratory work for these
interventions.
The efficacy of the static interventions in older adults at home will also be explored.
Power calculation: The investigators performed a power calculation for the primary outcome of
VO2 max in older adults using data from a previous study at our centre on home versus
laboratory HIIT. Assuming an effect size F of 0.6 for three groups and a within group SD of
5, the alpha level was set at 0.05 and the 1-beta at 0.80. This concluded that 30
participants would be required. To allow for potential non-completion and missing data 36
older participants will be enrolled to the study (12 to each group).
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