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A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors

Endometrial Cancer Clinical Trial

Official title:
A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors

Clinical Trial Summary

The purpose of this study is to assess the safety, tolerability and efficacy of the study drug AO-252 and identify the best dose for use in future studies.

Clinical Trial Description

The purpose of this study is to characterize the safety, tolerability including determination of maximum tolerated dose (MTD), and identify the recommended Phase 2 dose (RP2D). The study will also look at pharmacokinetics (PK), pharmacodynamics (PD) and preliminary anti-tumor activity of AO-252 as a monotherapy in participants with advanced or metastatic triple negative breast cancer (TNBC), high- grade serous ovarian carcinoma (HGSOC), and endometrial cancer ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06136884
Study type Interventional
Source A2A Pharmaceuticals Inc.
Contact Dr. Sotirios Stergiopoulos, MD, CEO
Phone 718-570-5029
Email clinicaltrials@a2apharma.net
Status Recruiting
Phase Phase 1
Start date November 2, 2023
Completion date January 27, 2027
View Details
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