High Grade Glioma Clinical Trial
Official title:
A Phase II Open-Label, Randomized, Multi-Centre Comparative Study Of Bevacizumab-Based Therapy In Paediatric Patients With Newly Diagnosed Supratentorial, Infratentorial Cerebellar, or Peduncular High-Grade Glioma
This randomized, open-label, multicenter, 2-arm study will investigate the efficacy, safety,
tolerability and pharmacokinetics of bevacizumab when added to postoperative radiotherapy
with concomitant and adjuvant TMZ as compared to postoperative radiotherapy with concomitant
and adjuvant TMZ alone in paediatric participants with newly diagnosed histologically
confirmed World Health Organization (WHO) Grade III or IV localized supratentorial or
infratentorial cerebellar or peduncular high grade glioma (HGG). Participants will be
randomly assigned to one of two treatment arms.
Upon approval by the Health Authorities/Ethics Committees in the participating countries, an
additional young participant cohort (YPC) (children >/= 6 months and < 3 years of age with
progressive or relapsed metastatic or localized, supra- or infratentorial, non-brain stem WHO
Grade III or IV HGG) was included in the study. Children in the YPC will receive bevacizumab
and TMZ without radiation therapy. The anticipated time on study treatment is over 1 year.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT05023551 -
Study of DSP-0390 in Patients With Recurrent High-Grade Glioma
|
Early Phase 1 | |
| Terminated |
NCT01902771 -
Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors
|
Phase 1 | |
| Active, not recruiting |
NCT02655601 -
Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001
|
Phase 2 | |
| Terminated |
NCT03690869 -
REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma
|
Phase 1/Phase 2 | |
| Completed |
NCT01466686 -
Low Dose Radiation Therapy for Glioblastoma Multiforme
|
Phase 2 | |
| Recruiting |
NCT05925218 -
Circulating Tumor DNA Collection From Patients With High Grade Gliomas
|
||
| Recruiting |
NCT05212272 -
MRI in High-Grade Glioma Patients Undergoing Chemoradiation
|
||
| Active, not recruiting |
NCT04911621 -
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06333899 -
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
|
Early Phase 1 | |
| Recruiting |
NCT04734444 -
SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue
|
N/A | |
| Completed |
NCT03775369 -
Glioma and Exercising
|
N/A | |
| Completed |
NCT02022644 -
Study of Convection-Enhanced, Image-Assisted Delivery of Liposomal-Irinotecan In Recurrent High Grade Glioma
|
Phase 1 | |
| Completed |
NCT00780819 -
Borderzone Sampling
|
N/A | |
| Recruiting |
NCT06072586 -
Study of BDTX-1535 in Recurrent High-Grade Glioma (HGG) Participants With EGFR Alterations or Fusions
|
Early Phase 1 | |
| Recruiting |
NCT03952598 -
Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy
|
N/A | |
| Recruiting |
NCT05630664 -
Liquid Biopsy in High-grade Gliomas and Meningiomas
|
||
| Recruiting |
NCT05298995 -
GD2-CAR T Cells for Pediatric Brain Tumours
|
Phase 1 | |
| Completed |
NCT01222754 -
Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas
|
Phase 1 | |
| Recruiting |
NCT05278208 -
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors
|
Phase 1/Phase 2 | |
| Completed |
NCT03355794 -
A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)
|
Phase 1 |