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Clinical Trial Summary

This study will evaluate the efficacy and safety of camrelizumab in combination with apatinib in in patients with relapsed or refractory diffuse large B cell lymphoma failed from second line chemotherapy.


Clinical Trial Description

Patients with relapsed /refractory diffuse large B cell lymphoma usually have a bad prognosis. These patients cannot be treated successfully with the conventional chemotherapy of CHOP. Apatinib is a new type of oral tyrosine kinase inhibitor targeting VEGFR-2. Some studies have shown that the combination of low-dose apatinib and camrelizumab shows a synergistic effect in the exploration of multiple solid tumors, and the adverse reactions of low-dose apatinib are significantly reduced, and the patients are well tolerated.The investigators will evaluate the efficacy and safety of camrelizumab in combination with apatinib in the patients with relapsed refractory diffuse large B cell lymphomafailed from second line chemotherapy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04476459
Study type Interventional
Source Sun Yat-sen University
Contact Huiqiang Huang, Professor
Phone +86 020 87343350
Email huanghq@sysucc.org.cn
Status Recruiting
Phase Phase 1/Phase 2
Start date July 23, 2020
Completion date August 1, 2023

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