IDH1 and OCT4 in High Grade Astrocytoma

High Grade Astrocytoma Clinical Trial

Official title:

IDH1 and OCT4 Markers as a Prognostic Factor in Clinical Outcome of High Grade Astrocytic Glioma

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06214689
• Other study ID #: biomarkers in astrocytoma
• Status: Not yet recruiting
• Start date: May 2024
• Est. completion date: April 2025

Study information

• Verified date: February 2024
• Source: Assiut University
• Contact: Abdelrahman A Salama, resident
• Phone: 01002796190
• Email: adhamsalama001[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

observation of IDH1 and OCT4 markers level and high grade astrocytoma patients prognosis after excision.

Description:

explore the relationship between prognosis and IDH1 and OCT4 biomarkers after high grade astrocytoma excision , according to progression free survival and overall survival , in prospective and retrospective samples.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 35
• Est. completion date: April 2025
• Est. primary completion date: January 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients of high grade astrocytic glioma patients fit for surgery

Exclusion Criteria:

• patients of low grade glioma patients unfit for surgery

Related Conditions & MeSH terms

• Astrocytoma
• High Grade Astrocytoma

Intervention

Other:
• biomarkers analysis
IDH1 and OCT4 markers analysis of surgical specimens of high grade astrocytoma

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (4)

Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS. The epidemiology of glioma in adults: a "state of the science" review. Neuro Oncol. 2014 Jul;16(7):896-913. — View Citation

Perry A, Wesseling P. Histologic classification of gliomas. Handb Clin Neurol. 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. — View Citation

PubMed

Sathornsumetee S, Rich JN, Reardon DA. Diagnosis and treatment of high-grade astrocytoma. Neurol Clin. 2007 Nov;25(4):1111-39, x. doi: 10.1016/j.ncl.2007.07.004. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	IDH1 and OCT4 markers and their relation to postoperative prognosis of high grade astrocytoma patients	explore the relationship between prognosis (progression free and overall survival ) and biomarkers (IDH1 and OCT4 ) after excision of high grade astrocytoma	baseline