High-flow Nasal Cannula Oxygen Clinical Trial
Official title:
Evaluating High-flow Nasal Cannula Oxygen Therapy Through Lung Ultrasound Score
Respiratory distress after extubation is associated with increased morbidity and mortality.
Its multifactorial pathophysiology causes a loss of pulmonary aeration during the weaning
process, the clinical translation being impaired gas exchange and the occurrence of
respiratory distress. Lung ultrasound can accurately quantify the loss of pulmonary aeration
before, after end during the weaning trial by calculating the Lung Ultrasound Score (LUS).
Investigators have recently demonstrated in a prospective two-center study of 100 patients
that the intensity of the lung aeration loss occurring during the weaning trial, was
predictive of the development of postextubation respiratory distress within 48 hours
following extubation. A LUS ≥ 14 could identify patients at high risk of developing
postextubation respiratory distress. A second study that investigators have just completed in
80 patients weaned from mechanical ventilation shows a 30% reduction of respiratory distress
in post-extubation High Flow Nasal Cannula oxygen group compared to a standard O2 group.
The establishment of a targeted therapeutic strategy proposed in a group of high-risk
patients, defined as having a ≥ 14 LUS at the end of the weaning trial could reduce the
incidence of extubation failure and associated morbidity and mortality.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02186288 -
Effect of High-flow Nasal Cannula Oxygen on Lung Volumes Determined by Electrical Impedance Tomography
|
N/A | |
| Recruiting |
NCT05759832 -
Modified HFNC Therapy for ARF Patients Undergoing Flexible Bronchoscopy
|
N/A |