Hidradenitis Suppurativa (HS) Clinical Trial
Official title:
The Role of Host-microbiota Interplay in Hidradenitis Suppurativa Pathogenesis
Hidradenitis Suppurativa (HS) is a chronic disabling inflammatory skin disorder associated with the development of painful and purulent lesions of the folds (armpits, inguinal folds, sub-mammary glands). HS most often develops in adolescence or young adulthood and is characterized by inflammation of the pilo-sebaceous system, of progressive severity (folliculitis, nodule, abscess, fistula). The pathogenesis of HS is still poorly understood: the fact that patients respond to combinations of antibiotics and/or immunosuppressive treatments suggests that the disease could be due to a dysregulated immune response against microbial skin flora. Unconventional lymphocytes (UL), classically considered being at the interface of innate and adaptive immunity, play an important role in immune protection against microbial flora. But UL dysfunction has also been reported in many autoimmune diseases involving various tissues (joints, digestive tract, skin). The uncontrolled and chronic activation of these UL by skin microbiota could therefore play a role in the pathogenesis of HS.
The aim of this exploratory study is to analyze the interplay between microbiota and the innate and adaptative immune response in the pathogenesis of HS. To better understand this host-microbiota interplay, we will assess the number, frequency and functional phenotypes of the different lymphocyte subsets in HS patients, with a special focus regarding the UL. In the same time, we will assess the diversity and nature of skin microbiota of the same patients. Finally, we will explore the relation between the immune response and the skin microbiota in HS, using correlation analysis (Spearman coefficient). In this study, HS patients will be their own control for leucocyte phenotyping, cytokine analysis and T Cells Receptor (TCR) sequencing (skin biopsies) and for skin microbiota analysis. Paired (age/sex) healthy volunteers will be controls for gut microbiota analysis and for immunophenotyping of circulating leukocytes (Peripheral Blood Mononuclear Cells (PBMC) analysis). ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03173144 -
Chronic Inflammatory Disease, Lifestyle and Treatment Response
|
||
| Completed |
NCT02896920 -
Canadian Humira Post Marketing Observational Epidemiological Study : Assessing Humira Real-life Effectiveness and Impact on HS Burden of Illness
|
||
| Completed |
NCT01468207 -
Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa
|
Phase 3 | |
| Completed |
NCT01468233 -
Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa
|
Phase 3 | |
| Completed |
NCT03894956 -
Observational Study Evaluating Long-Term Safety and Effectiveness of Humira in Patients With Hidradenitis Suppurativa
|
||
| Completed |
NCT03001115 -
Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa Subjects
|
||
| Not yet recruiting |
NCT05723757 -
Autophagy Dysfunction in Hidradenitis Suppurativa
|
N/A | |
| Completed |
NCT02808975 -
Safety and Efficacy of Adalimumab (Humira) for Hidradenitis Suppurativa (HS) Peri-Surgically
|
Phase 4 | |
| Completed |
NCT04430855 -
A Study of Oral Upadacitinib Tablet Compared to Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa to Assess Change in Disease Symptoms
|
Phase 2 | |
| Recruiting |
NCT06212999 -
A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
|
Phase 3 | |
| Active, not recruiting |
NCT04354012 -
Hidradenitis Suppurativa Wound Care
|
Phase 2 | |
| Completed |
NCT03487276 -
Efficacy and Safety Study of IFX-1 in Patients With Moderate to Severe Hidradenitis Suppurativa (HS)
|
Phase 2 | |
| Recruiting |
NCT05620836 -
A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa (HS)
|
Phase 3 | |
| Recruiting |
NCT05620823 -
A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa
|
Phase 3 | |
| Recruiting |
NCT06241573 -
A Study to Test Long-term Treatment With Spesolimab in People With a Skin Condition Disease Called Hidradenitis Suppurativa (HS) Who Took Part in a Previous Study With Spesolimab
|
Phase 2/Phase 3 | |
| Available |
NCT05583604 -
Secukinumab Global MAP Cohort for Adult Patients With Hidradenitis Suppurativa (HS)
|