Effect of Stress on Heroin-Related Memory Retrieval

Heroin Dependence Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00759005
• Other study ID #: NIDD
• Status: Completed
• Phase: N/A
• First received: September 23, 2008
• Last updated: September 23, 2008
• Start date: March 2007
• Est. completion date: September 2008

Study information

• Verified date: September 2008
• Source: National Institute on Drug Dependence, China
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Peking University Research Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: September 2008
• Est. primary completion date: June 2008
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion Criteria:

• current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).

Study Design

N/A

Related Conditions & MeSH terms

• Heroin Dependence
• Learning and Memory

Intervention

Drug:
• propranolol and cortisol

Locations

Country	Name	City	State
China	National Institute on Drug Dependence	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
National Institute on Drug Dependence, China

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts			Yes