Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1

Heroin Dependence Clinical Trial

Official title:

Buprenorphine/Naloxone Versus Clonidine For Out-patient Opiate Detoxification

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00032968
• Other study ID #: NIDA-CTN-0002-1
• Status: Completed
• Phase: Phase 3
• First received: April 5, 2002
• Last updated: January 11, 2017
• Start date: January 2001
• Est. completion date: August 2002

Study information

• Verified date: April 2010
• Source: National Institute on Drug Abuse (NIDA)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to assess buprenorphine/naloxone versus clonidine for outpatient opiate detoxification.

Description:

Patients randomized to the BUP/NX arm will receive daily doses for 13 days with sublingual administration of 2 mg buprenorphine/0.5 mg naloxone tablet(s) and/or an 8 mg buprenorphine/2.0 mg naloxone tablet(s). The starting dose on day 1 is 4 mg/1 mg BUP/NX with an additional 4 mg/1 mg, if needed, escalating in a step-wise manner to 16 mg/4 mg BUP/NX on day 3 and tapering to 2 mg/ 0.5 mg BUP/NX by days 12 to 13. Patients randomized to the clonidine arm will receive oral clonidine (0.05 to 0.1 mg depending upon weight) every 4 to 6 hours for 24 hours not to exceed 0.6 mg total on day 1. On day 2, a clonidine transdermal patch will be applied (0.1 mg/day/7-day patch with number of patches adjusted by weight). Oral clonidine will continue to be given on the second day of detoxification and increased to 0.2 mg every 6 hours or 0.1 mg every 3 hours not to exceed 0.8 mg over 24 hours. Patches will be worn all 13 days of detoxification. The dose of clonidine will be adjusted according to the proposed detoxification schedule, patient's weight, tolerance, and systolic blood pressure. Patients will receive counseling according to procedures in existence at each CTP throughout the study. Self-help detoxification handbooks will be distributed to all study participants.

Other known NCT identifiers

• NCT00016757

Recruitment information / eligibility

• Status: Completed
• Enrollment: 341
• Est. completion date: August 2002
• Est. primary completion date: August 2002
• Accepts healthy volunteers: No
• Gender: All
• Age group: 15 Years and older

Eligibility

Inclusion Criteria:

1. Treatment-seeking males and non-pregnant and non-lactating females, 15 years and older, who fulfill DSM-IV criteria for opiate dependence, report experiencing symptoms of opiate withdrawal, are currently physically dependent on opioids and are in need of medical assistance for opioid withdrawal.

2. Systolic blood pressure 100 mm Hg, and pulse 56 bpm.

3. Good general health or, in case of a medical/psychiatric condition needing ongoing treatment, under the care of a physician willing to continue patient's medical management and cooperate with the study physicians.

4. Agreeable to and capable of signing the informed consent approved by an institutional review board and, if under the age of 18 (excluding emancipated minors), assent and concurrent consent from a parent or legal guardian.

5. Use of one of the following acceptable methods of birth control by female patients of childbearing potential:

1. oral contraceptives

2. barrier (diaphragm or cervical cap) with spermicide or condom

3. intrauterine progesterone contraceptive system

4. levonorgestrel implant

5. medroxyprogesterone acetate contraceptive injection

6. complete abstinence from sexual intercourse

Exclusion Criteria:

1. Medical condition that would make participation, in the opinion of the study physician, medically hazardous (e.g., acute hepatitis, unstable cardiovascular, liver or renal disease);

2. Clinically significant abnormalities in ECG.

3. Known allergy or sensitivity to buprenorphine, naloxone, or clonidine.

4. Receiving beta-blockers, calcium channel blockers, tricyclics, digitalis and other medications which may interact adversely with clonidine.

5. Acute severe psychiatric condition in need of immediate treatment, or imminent suicide risk.

6. Dependence on alcohol, benzodiazepines or other depressants, or stimulants, and requiring immediate medical attention.

7. Participation in an investigational drug study, including buprenorphine, within the past 30 days.

8. Methadone or LAAM maintenance or detoxification within 30 days of enrollment.

9. Pending legal action that could prohibit or interfere with participation.

10. Unable to remain in area for duration of active phase of treatment.

11. Females that are pregnant, lactating, or planning to become pregnant.

Study Design

Allocation: Randomized, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Heroin Dependence
• Morphine Dependence
• Substance Withdrawal Syndrome

Intervention

Drug:
• Buprenorphine/naloxone

Locations

Country	Name	City	State
United States	Haight-Ashbury Free Clinic	Berkeley	California
United States	Addiction Research and Treatment Corp	Brooklyn	New York
United States	Midtown Community Mental Health Center	Indianapolis	Indiana
United States	Bellevue	New York	New York
United States	Aegis Medical Systems, Inc.	Oxnard	California
United States	UMDNJ - Robert Wood Johnson Medical School	Piscataway	New Jersey
United States	Kaiser Permanente Northwest, Division of Addiction	Portland	Oregon

Sponsors (1)

Lead Sponsor	Collaborator
University of California, Los Angeles

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Drug use
Primary	Degree of drug craving
Primary	Opiate craving
Primary	Adverse events
Primary	Drug craving
Primary	Decreased frequency of HIV related behavior
Primary	Adverse effect measures

External Links

•   Data Elements