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Clinical Trial Summary

Opioid abuse is a complex problem, which not only impacts on the affected individuals' physical and psychological health, but also threatens public security and the productivity of the society. Further, through needle sharing and sexual contacts, injecting drug users (IDUs) have become laden with HIV and HIV related health problems, representing a serious public health threat all over the world. In Taiwan, since the identification of the first HIV-infected IDU in 1987, the incident cases have continued to increase, reaching a height of 2,461 in 2005. In order to contain the epidemics of HIV among IDUs, and to prevent its spread to the population in general, the Center for Disease Control (CDC) collaborated with the Department of Justice to initiate and implement a number of harm reduction programs in 2005. The fact that opioid addiction is officially treated as a health rather than a legal issue itself represents a remarkable milestone in Taiwan. Among these harm reduction programs, including needle and syringe exchange for IDUs as well as substitution treatment approaches for opioid dependence, methadone maintenance treatment (MMT) perhaps represents the most most important and most crucial component. Remarkably, in a relatively short time span, more than 60 MMT programs were established, which enrolled more than 15,000 heroin addicts. This notwithstanding, the overall and differential effectiveness of these MMT service delivery systems, as well as the characteristics of these programs and the patients that might contribute toward treatment response or failure remain largely unknown. Such knowledge base is crucial for establishing standardized and feasible outcome evaluation processes for opioid addicts receiving MMT programs, as well as for the further improvement of the efficacy and effectiveness of these programs, in Taiwan.

In order to address some of these issues, this study adopts a multi-site, prospective clinical follow-up design. It aims at establishing a research network for examining MMT outcome, developing standardized MMT outcome assessment instruments and procedures, and identifying predictors of MMT outcome. The findings may contribute to the better understanding of the characteristics of opioid addicts, the effectiveness of MMT and remaining service needs for opioid addicts in Taiwan.


Clinical Trial Description

n/a


Study Design

Observational Model: Case-Only, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT01093248
Study type Observational
Source National Health Research Institutes, Taiwan
Contact Chun-Yu Chen, MS
Phone 886-37-246166
Email cyc@nhri.org.tw
Status Recruiting
Phase N/A
Start date July 2009
Completion date December 2012

See also
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Completed NCT00574067 - Buprenorphine for Prisoners Phase 3
Completed NCT00378079 - Methadone Maintenance for Prisoners Phase 3
Completed NCT01457872 - Malmö Treatment Referral and Intervention Study N/A
Active, not recruiting NCT04086459 - PET/MRI Study on the Neurological Mechanism of rTMS Treatment for Heroin Addiction N/A
Completed NCT02062736 - Observational Study to Assess the Adequacy of Methadone Dosage, in Heroin Addicted Patients in a MMT. N/A
Not yet recruiting NCT01668732 - Decision Making Deficit and DNA Methylation in Opioid Receptor Genes Among Community Heroin Addicts N/A
Unknown status NCT00750217 - Transfer From Methadone to Buprenorphine Maintenance Treatment Using Buprenorphine Patches Phase 4