Parental Consanguinity and Family History of Kidney Disease in Turkish Kidney Disease Population

Hereditary Diseases Clinical Trial

— CAKD  

Official title:

The Importance of Parental Consanguinity and Family History of Kidney Disease in Turkish Adult Chronic Kidney Disease Population

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02917070
• Other study ID #: 2016/257
• Secondary ID: 301
• Status: Completed
• Phase: N/A
• First received: September 9, 2016
• Last updated: September 26, 2016
• Start date: February 2016
• Est. completion date: August 2016

Study information

• Verified date: September 2016
• Source: Istanbul University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ethics Committee
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.

Description:

This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2576
• Est. completion date: August 2016
• Est. primary completion date: May 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty

• between 18-70 years old

• provide informed consent

Exclusion Criteria:

• follow-up shorter than 6 months

• patients whose data were not available

• patients who were unwilling or unable to provide informed consent

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Genetic Diseases, Inborn
• Hereditary Diseases
• Kidney Diseases

Intervention

Other:
• Patients
In this study we aimed to investigate effect of family history and consanguineous marriage in the development of CKD in the adult Turkish population.

Locations

Country	Name	City	State
Turkey	Istanbul University, Istanbul Faculty of Medicine	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Istanbul University

Country where clinical trial is conducted

Turkey, 

References & Publications (5)

Chronic Kidney Disease Prognosis Consortium, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortalit — View Citation

Gumprecht J, Zychma MJ, Grzeszczak W, Zukowska-Szczechowska E; End-stage Renal Disease Study Group. Human SA gene Pst1 polymorphism and chronic renal failure: results of the family-based study. Nephrol Dial Transplant. 2001 Feb;16(2):387-90. — View Citation

National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002 Feb;39(2 Suppl 1):S1-266. — View Citation

O'Dea DF, Murphy SW, Hefferton D, Parfrey PS. Higher risk for renal failure in first-degree relatives of white patients with end-stage renal disease: a population-based study. Am J Kidney Dis. 1998 Nov;32(5):794-801. — View Citation

Süleymanlar G, Utas C, Arinsoy T, Ates K, Altun B, Altiparmak MR, Ecder T, Yilmaz ME, Çamsari T, Basçi A, Odabas AR, Serdengeçti K. A population-based survey of Chronic REnal Disease In Turkey--the CREDIT study. Nephrol Dial Transplant. 2011 Jun;26(6):186 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not.		6 months after enrollment	No
Secondary	Effect of family history of kidney disease on the development of chronic kidney confirmed by a questionnaire did they have any parents with chronic kidney diseases or not.		6 months after enrollment	No

External Links

•   Registry of the nephrology, dialysis and transplantation in turkey: ministry of health and turkish society of nephrology joint report