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NCT00004306 Clinical Trial

Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 10 (SCA10)

Hereditary Ataxia Clinical Trial

Official title:
Pathogenic Mechanism of Spinocerebellar Ataxia Type 10 (SCA10)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00004306
Other study ID # 199/11796
Secondary ID
Status Completed
Phase N/A
First received October 18, 1999
Last updated March 5, 2012
Start date November 1999
Est. completion date March 2009

Study information
Verified date March 2012
Source Office of Rare Diseases (ORD)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

OBJECTIVES: I. Clinically evaluate members from families with a dominantly inherited ataxia and collect blood, skin and muscle samples for detailed molecular studies.

II. Perform detailed clinical evaluations on patients with recessively inherited ataxias.

Description:

PROTOCOL OUTLINE: Participants undergo a comprehensive clinical and molecular evaluation. Studies include: neurologic evaluation, including magnetic resonance imaging and nerve conduction studies; ophthalmologic exam; audiologic exam, including auditory brain stem evoked response; DNA extraction from blood, skin and muscle; genotype phenotype correlation.

A neuropathologic evaluation is conducted postmortem, when possible.

Recruitment information / eligibility
Status Completed
Enrollment 18
Est. completion date March 2009
Est. primary completion date March 2009
Accepts healthy volunteers No
Gender Both
Age group 3 Years and older
Eligibility Inclusion criteria:

Subjects who have the diagnosis of SCA10 and their immediate relatives.

Exclusion criteria:

Children under 3 years of age, pregnant women, prisoners, mentally incapacitated subjects, and subjects who do not give consent.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
United States University of Texas Medical Branch at Galveston Galveston Texas

Sponsors (2)
Lead Sponsor Collaborator
Office of Rare Diseases (ORD) The University of Texas Medical Branch, Galveston

Country where clinical trial is conducted

United States, 

See also
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Recruiting NCT05160883 - Neuroimaging Changes in Hereditary Ataxia
Recruiting NCT05160870 - Genotype-phenotype Correlation and Pathogenic Mechanism in Hereditary Ataxia
Completed NCT00202397 - Effect of Riluzole as a Symptomatic Approach in Patients With Chronic Cerebellar Ataxia Phase 2
Recruiting NCT01360164 - Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Hereditary Ataxia Phase 1/Phase 2