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Clinical Trial Summary

This study evaluates the efficacy of orally administered deucrictibant for the acute treatment of attacks in patients with hereditary angioedema (HAE). Eligible subjects are randomized to one of three single doses of deucrictibant and placebo. The study will compare symptom relief (skin pain, skin swelling, abdominal pain) during HAE attacks and safety of each dose of deucrictibant with placebo.


Clinical Trial Description

In Part I of the study, patients in non-attack state receive the assigned active single dose of deucrictibant at the study center to assess pharmacokinetics (the way the body absorbs, distributes, and gets rid of the drug) and safety. In Part II of the study, patients self-administer blinded study drug at home to treat three HAE attacks with deucrictibant or placebo (cross-over). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04618211
Study type Interventional
Source Pharvaris Netherlands B.V.
Contact
Status Completed
Phase Phase 2
Start date February 3, 2021
Completion date March 1, 2023

See also
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