HER2-positive Breast Cancer Clinical Trial
Official title:
Phase I Multicenter, Open-Label, First-in-Human Study of ORM-5029 in Subjects With HER2-Expressing Advanced Solid Tumors
This is a Phase 1 first-in-human study of ORM-5029 in participants with HER2-expressing advanced solid tumors. The study consists of two parts: a Part 1 Dose Escalation and Part 2 Dose Expansion.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
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Phase 2 | |
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Phase 2 | |
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Phase 2 | |
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Phase 2 | |
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Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With Locally Advanced or Metastatic HER2-Positive Breast , Gastric, or Gastroesophageal Cancer That Cannot Be Removed By Surgery
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Phase 1 | |
| Recruiting |
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TCHP Versus EC -THP as Neoadjuvant Treatment for HER2-Positive Breast Cancer
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Phase 2 | |
| Recruiting |
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Investigate the Prognostic and Predictive Value of ctDNA During Neoadjuvant Chemotherapy for Breast Cancer.
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| Recruiting |
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Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
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Phase 2 | |
| Recruiting |
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Pyrotinib Rechallenge in Her2-positive Metastatic Breast Cancer Pretreated With Pyrotinib and Trastuzumab
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Phase 3 | |
| Completed |
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PRS-343 in HER2-Positive Solid Tumors
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Phase 1 | |
| Recruiting |
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Dalpiciclib in Combination With Exemestane and Trastuzumab Plus Pyrotinib in Early Triple Positive Breast Cancer
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Phase 2 | |
| Not yet recruiting |
NCT04034823 -
KN035 in Combination With Trastuzumab and Docetaxel in HER2-positive Breast Cancer
|
Phase 2 | |
| Completed |
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18F-FDG Uptake Heterogeneity Predicts Pyrotinib Response
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| Completed |
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TCH Versus EC-TH as Neoadjuvant Treatment for HER2-Positive Breast Cancer
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Phase 2 | |
| Completed |
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Incidence and Severity of Diarrhea in Patients With HER2 Positive Breast Cancer Treated With Trastuzumab and Neratinib
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Phase 2 | |
| Recruiting |
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Phase 2 | |
| Recruiting |
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Real World Patient-Reported Outcomes in Chinese Her2+ EBC Patients Receiving (Neo) Adjuvant Anti-Her2 Based Therapy
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| Recruiting |
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Neoadjuvant Trastuzumab Deruxtecan (T-DXd) With Response-directed Definitive Therapy in Early Stage HER2-positive Breast Cancer (SHAMROCK Study)
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Phase 2 | |
| Not yet recruiting |
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Cardiotoxicity of Targeted Therapy for HER-2 Positive Breast Cancer Patients at High Altitude
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| Not yet recruiting |
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Capecitabine in HER-2 Positive Breast Cancer With Pathologic Residual Tumors After Preoperative Chemotherapy
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Phase 2 |