Hepatopathy Clinical Trial
Official title:
Prognosis Factors of Cardiac Complications After Liver Transplantation
This is a prospective, multicenter, non-interventional, observational study of a cohort with a biological plasma and urine samples collection for the study of prognosis factors of cardiac complications after liver transplantation
Liver transplantation (LT) is the standard treatment for chronic or acute hepatic
insufficiency with 87% of one-year survival. Cardiovascular complications are common after LT
with an incidence at 6 months ranging between 25 and 50 %. These complications are associated
with significant morbidity and represents the third cause of post LT mortality. Myocardial
perfusion imaging or stress echocardiography, used for preoperative cardiovascular
evaluation, are not enough efficient to predict the risk of post LT cardiovascular
complications. However, to improve the prediction capacity of cardiovascular disease is
fundamental in order to better select the candidates for LT or to develop preventive
strategies. Such a strategy could reduce the morbidity and mortality from cardiovascular
diseases after LT and improve the results of LT. Cardiovascular biomarkers such as troponin
or natriuretic peptide are known to be predictive factors of postoperative cardiovascular
complications in non cardiac surgery. The use of biomarkers in combination with conventional
tests could improve the preoperative prediction of post LT cardiovascular complications.
Hypothesis: The preoperative biomarkers dosage could improve the prediction of cardiovascular
complications occurring in the year after LT.
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