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Clinical Trial Summary

This is a single arm, open-label, uni-center, phase I-II study to evaluate the safety and effectiveness of CAR-T/TCR-T cell immunotherapy in treating with different malignancies patients.


Clinical Trial Description

The study is a multi-target gene-modified immunotherapy. CAR-T/TCR-T cells include ten different tumor-specific antibody.They are as following:anti-CD19 antibody for B cell leukemia and lymphoma;anti-CD22 antibody for B cell leukemia and lymphoma;anti-CD33 antibody for myeloid leukemia;anti-BCMA antibody for multiple myeloma;anti-CD38 antibody for multiple myeloma;anti-NY-ESO-1 antibody for multiple myeloma,esophagus cancer,lung cancer,melanoma and synovial sarcoma;anti-DR5 antibody for hepatoma;anti-C-met antibody for hepatoma,colorectal cancer,ovarian cancer and renal carcinoma;anti-EGFR V III antibody for hepatoma,lung cancer and glioma;anti-Mesothelin antibody for gastric cancer,pancreatic cancer and mesothelioma. ;


Study Design


Related Conditions & MeSH terms

  • B-cell Acute Lymphoblastic Leukemia
  • Burkitt Lymphoma
  • Carcinoma, Renal Cell
  • Colorectal Cancer
  • Esophageal Neoplasms
  • Esophagus Cancer
  • Gastric Cancer
  • Glioma
  • Hepatoma
  • Kidney Neoplasms
  • Leukemia
  • Lung Cancer
  • Lymphoma
  • Melanoma
  • Mesothelioma
  • Multiple Myeloma
  • Myeloid Leukemia
  • Ovarian Cancer
  • Pancreatic Cancer
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Renal Carcinoma
  • Sarcoma, Synovial
  • Synovial Sarcoma

NCT number NCT03638206
Study type Interventional
Source Shenzhen BinDeBio Ltd.
Contact ZhongHua Yang
Phone 18938688105
Email zh.yang@bindebio.com
Status Recruiting
Phase Phase 1/Phase 2
Start date March 1, 2018
Completion date March 1, 2023

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