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Sofosbuvir/Pegylated-interferon Plus Ribavirin With HCV Genotype 4 — HCV  

Hepatitis C Virus Infection Clinical Trial

Official title:
Effectiveness of Sofosbuvir/Pegylated-interferon Plus Ribavirin in Treatment of Hepatitis C Virus Genotype 4 Patients

Clinical Trial Summary

This study aims to assess the efficacy and safety of sofosbuvir (SOF) with pegylated interferon (PegINF)/ribavirin (RBV) for chronic HCV GT4 participants

Clinical Trial Description

Between March 2015 and November 2015, 99 participants (59 naïve and 40 experienced) infected with HCV GT4 were enrolled in the study. Eligible participants received daily oral 400 mg SOF ( (Sovaldi, Gilead Sciences, Inc., USA), RBV (Copegus, Roche, Europe) based on body weight: < 75 kg, 1000 mg; ≥75 kg, 1200 mg), the dose modified according to participants tolerability, plus 180 μg PegINFα-2 once weekly for 12 weeks.

Experienced participants included participants with a prior relapse or a null response to PegINF/RBV therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04382339
Study type Interventional
Source Beni-Suef University
Contact
Status Completed
Phase Phase 1/Phase 2
Start date March 2015
Completion date November 2015
View Details
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